2011 Fiscal Year Final Research Report
Devwlopment of novel functional peptides that induce ubiquitin-dependent proteolysis of virulence protein
| Project/Area Number |
22750153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
YAMAYOSHI Asako 京都工芸繊維大学, 工芸科学研究科, 助教 (70380532)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ユビキチン / 核酸 / ペプチド / 分子標的薬 / ガン |
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| Research Abstract |
The mechanism to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, 26S proteasome performs the selective degradation of ubiquitynated proteins. We designed and evaluated new functional-decoy,"Degron-decoy", which is expected to recruit ubiquitin ligase and induce ubiquitin-dependent of target proteins.
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