2011 Fiscal Year Final Research Report
Understanding the functioning of the respiratory enzyme nitric oxide reductase through computer simulations
| Project/Area Number |
22770163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
PISLIAKOV Andrei 独立行政法人理化学研究所, 杉田理論生物化学研究室, 国際特別研究員 (70565770)
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| Project Period (FY) |
2010 – 2011
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| Keywords | membrane proteins / respiratory enzymes / nitric oxide reductase / MD simulation / water dynamics / proton transfer |
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| Research Abstract |
We investigated proton pathways in nitric oxide reductases(cNOR and qNOR types), both in wild-type proteins and in silico mutants. Results provide insights into proton uptake mechanism of NORs and shed light on molecular evolution of respiratory enzymes.
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