2011 Fiscal Year Final Research Report

Analysis of crosstalk between DNA repair and gene expression control

Research Project

Project/Area Number	22770171
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Molecular biology
Research Institution	Osaka University
Principal Investigator	NARITA Takashi 大阪大学, 生命機能研究科, 助教 (50437399)
Research Collaborator	KOH Dawn xin ping 大阪大学, 生命機能研究科, 大学院生
Project Period (FY)	2010 – 2011
Keywords	DNA修復 / 発現制御 / 転写
Research Abstract	The aim of this study is to investigate the crosstalk between DNA repair factors and transcription factors so that genetic disorders caused by defects in DNA repair system can be understood at a molecular level. The results show that XPG, which is involved in nucleotide excision repair, interacts with some transcription factors as well as general transcription factor TFIIH, and that the function of XPG in transcription is closely related to clinical features found in XP-G patients.