2011 Fiscal Year Final Research Report
Analysis of crosstalk between DNA repair and gene expression control
Project/Area Number |
22770171
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Molecular biology
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Research Institution | Osaka University |
Principal Investigator |
NARITA Takashi 大阪大学, 生命機能研究科, 助教 (50437399)
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Research Collaborator |
KOH Dawn xin ping 大阪大学, 生命機能研究科, 大学院生
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Project Period (FY) |
2010 – 2011
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Keywords | DNA修復 / 発現制御 / 転写 |
Research Abstract |
The aim of this study is to investigate the crosstalk between DNA repair factors and transcription factors so that genetic disorders caused by defects in DNA repair system can be understood at a molecular level. The results show that XPG, which is involved in nucleotide excision repair, interacts with some transcription factors as well as general transcription factor TFIIH, and that the function of XPG in transcription is closely related to clinical features found in XP-G patients.
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[Journal Article] MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation2010
Author(s)
Shinsuke Ito, Li-Jing Tan, Daisuke Andoh, Takashi Narita, Mineaki Seki, Yasuhiro Hirano, Keiko Narita, Isao Kuraoka, Yasushi Hiraoka, Kiyoji Tanaka
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Journal Title
Mol. Cell
Volume: 39
Pages: 632-640
DOI
Peer Reviewed
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