2011 Fiscal Year Final Research Report
An analysis of mechanical control of the proportion of a tissue
| Project/Area Number |
22770228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University (2011)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
SUGIMURA Kaoru 京都大学, 物質細胞統合システム拠点, 助教 (50466033)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Shuji 東京大学, 総合文化研究科, 助教 (10401217)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 器官形成 / 力 |
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| Research Abstract |
Mechanical properties of a growing tissue are indispensable to understand developmental processes responsible for determining the final size, shape and proportion of a tissue. In the present study, we studied whether mechanical force regulates an axis of cell division to support the correct patterning of multi-cellular tissues. By using a newly developed force-estimation technique, we clarified a correlation between the angular distribution of cell division and the directionality of the stress field of a tissue. Moreover, our numerical simulation of tissue growth suggested that the experimentallyobserved rules of cell divisions contribute robustness of the tissue shape.
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