2011 Fiscal Year Final Research Report
Elucidation of molecular basis of specificity in biosynthetic regulation and action mechanisms of antimicrobial peptides from lactic acid bacteria
| Project/Area Number |
22780069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kyushu University |
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Principal Investigator |
ZENDO Takeshi 九州大学, 農学研究院, 助教 (50380556)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 微生物機能 / 乳酸菌 / 抗菌ペプチド / バクテリオシン |
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| Research Abstract |
Structures of antimicrobial peptides, bacteriocins, from lactic acid bacteria were analyzed, and some novel bacteriocins such as enterocin W, leucocyclicin Q and weissellicins YM were identified. Biosynthetic genes and their functions of some bacteriocins such as lacticin Q, enterocins NKR-5-3 and weissellicins YM were analyzed, and their biosynthetic regulation systems were partly unraveled. Action mechanisms of some bacteriocins were studied, and some factors for their specific antimicrobial actions were revealed.
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