2011 Fiscal Year Final Research Report
Role of homeodomein transcription factor Meis1 on the maintain and differentiation of spermatogonial stem cell
| Project/Area Number |
22780264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KAWAI Yasuhiro 東京理科大学, 生命科学研究所, 助教 (00416281)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 発生 |
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| Research Abstract |
The maintenance, self-renewal, and differentiation of spermatogonial stem cells(SSCs) are tightly regulated processes that are critical for normal spermatogenesis. However, molecular mechanisms controlling these processes remain largely unclear. TALE family homeodomain transcription factors, including Meis1 and pKnox1, are demonstrated to be essential for hematopoietic stem cell maintenance and self-renewal. In this study, our results indicated that these transcription factors were required for differentiation and proliferation of spermatogonia.
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