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2011 Fiscal Year Final Research Report

Flavivirus-specific antiviral activity of 2'-5'-oligoadenylate synthetases

Research Project

  • PDF
Project/Area Number 22780268
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

YOSHII Kentaro  北海道大学, 大学院・獣医学研究科, 助教 (50421988)

Research Collaborator TAKASHIMA Ikuo  北海道大学, 大学院・獣医学研究科, 名誉教授 (30002083)
KARIWA Hiroaki  北海道大学, 大学院・獣医学研究科, 准教授 (70224714)
AGUI Takashi  北海道大学, 大学院・獣医学研究科, 教授 (00212457)
Project Period (FY) 2010 – 2011
Keywords人獣共通感染症
Research Abstract

The interferon-inducible 2'-5'-oligoadenylate synthetases(OAS) play important roles in the antiviral activity against RNA virus infection. The murine isoform Oas1b gene has been identified as a critical determinant for genetic susceptibility to flavivirus infection. In this study, we analyzed the mechanism of the flavivirus-specific antiviral activity of Oas1b, and indicated that OAS plays crucial roles in the pathogenesis of flavivirus.

  • Research Products

    (40 results)

All 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 14 results) Presentation (20 results) Book (2 results)

  • [Journal Article] The Conserved Region in the PrM Protein Is a Critical Determinant in the Assembly of Flavivirus Particles2012

    • Author(s)
      Yoshii K, Igarashi M, Ichii O, Yokozawa K, Ito K, Kariwa H, Takashima I
    • Journal Title

      J Gen Virol

      Volume: 93 Pages: 27-38

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of hantaviruses in far East Russia and etiology of hemorrhagic Fever with renal syndrome in the region2012

    • Author(s)
      Kariwa H, Yoshii K, Takashima I(他11名. 13番目)
    • Journal Title

      Am J Trop Med Hyg

      Volume: 86 Pages: 545-553

    • Peer Reviewed
  • [Journal Article] Genetic diversity of hantaviruses in Mexico : Identification of three novel hantaviruses from Neotominae rodents2012

    • Author(s)
      Kariwa H, Yoshii K, Takashima I(他15名. 15番目)
    • Journal Title

      Virus Res

      Volume: 163 Pages: 486-494

    • Peer Reviewed
  • [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice2012

    • Author(s)
      Seto T, Yoshii K, Kariwa H(他8名. 9番目)
    • Journal Title

      Virus Res

      Volume: 163 Pages: 284-290

    • Peer Reviewed
  • [Journal Article] Needle-Free Jet Injection of DNA and Protein Vaccine of the Far-Eastern Subtype of Tick-Borne Encephalitis Virus Induced Protective Immunity in Mice2011

    • Author(s)
      Omori-Urave K, Yoshii K, Ikawa-Yoshida A, Kariwa H, Takashima I
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 893-897

    • Peer Reviewed
  • [Journal Article] Glycosylation of the Envelope Protein of West Nile Virus Affects its Replication in Chicks2011

    • Author(s)
      Totani M, Yoshii K, Kariwa H, Takashima I
    • Journal Title

      Avian Diseases

      Volume: 55 Pages: 561-568

    • Peer Reviewed
  • [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus2011

    • Author(s)
      Takano A, Yoshii K, Omori-Urabe Y, Yokozawa K, Kariwa H, Takashima I
    • Journal Title

      Arch Virol

      Volume: 156 Pages: 1931-1941

    • Peer Reviewed
  • [Journal Article] Puumala virus infection in Syrian hamsters(Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts2011

    • Author(s)
      Sanada T, Kariwa H, Yoshii K(他6名. 8番目)
    • Journal Title

      Virus Res

      Volume: 160 Pages: 108-119

    • Peer Reviewed
  • [Journal Article] Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS52011

    • Author(s)
      Yoshii K, Igarashi M, Ito K, Kariwa H, Holbrook MR, Takashima I
    • Journal Title

      Virus Res

      Volume: 155 Pages: 61-68

    • Peer Reviewed
  • [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan2011

    • Author(s)
      Yoshii K, Kariwa H, Takashima I(他12名. 1番目)
    • Journal Title

      Vet Med Sci

      Volume: 73 Pages: 409-12

    • Peer Reviewed
  • [Journal Article] Seroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test2011

    • Author(s)
      Murata R, Hashiguchi K, Yoshii K, Kariwa H, Nakajima K, Ivanov LI, Leonova GN, Takashima I
    • Journal Title

      Am J Trop Med Hyg

      Volume: 84 Pages: 461-465

    • Peer Reviewed
  • [Journal Article] Development of ELISA system for tick-borne encephalitis virus infection in rodents2011

    • Author(s)
      Ikawa-Yoshida A, Yoshii K, Kuwahara K, Obara M, Kariwa H, Takashima I
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 100-107

    • Peer Reviewed
  • [Journal Article] An Efficient in vivo Method for THE Isolation OF PUUMALA VIRUS IN SYRIAN Hamsters and the Characterization of the isolates from Russia2011

    • Author(s)
      Seto K, Yoshii K, Kariwa H(他17名. 15番目)
    • Journal Title

      J Virol Methods

      Pages: 17-23

    • Peer Reviewed
  • [Journal Article] 日本国内におけるダニ媒介性脳炎の血清疫学調査2011

    • Author(s)
      好井健太朗, 持舘景太, 苅和弘明, 高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 64 Pages: 801-803

  • [Journal Article] ダニ媒介性脳炎2011

    • Author(s)
      苅和宏明, 好井健太朗, 高島郁夫
    • Journal Title

      公衆衛生

      Volume: 75 Pages: 36-38

  • [Journal Article] Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds2010

    • Author(s)
      Murata R, Yoshii K, Takashima I(他7名. 7番目)
    • Journal Title

      Am J Trop Med Hyg

      Volume: 82 Pages: 696-704

    • Peer Reviewed
  • [Journal Article] ダニ媒介性脳炎2010

    • Author(s)
      好井健太朗, 苅和宏明, 高島郁夫
    • Journal Title

      北海道獣医師会雑誌

      Volume: 54 Pages: 2-7

  • [Journal Article] ウエストナイルウイルスの鳥類における増殖性と極東ロシアでの抗体調査2010

    • Author(s)
      村田亮, 好井健太朗, 苅和宏明, 高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 63 Pages: 208-9

  • [Presentation] リバースジェネティクスを用いた極東型ダニ媒介性脳炎ウイルスの病原性決定因子の解析2011

    • Author(s)
      境瑞紀、好井健太朗、高野絢子、大森優紀、横澤香菜、苅和宏明、高島郁夫
    • Organizer
      第18回トガ・フラビ・ペスチウイルス研究会
    • Year and Date
      2011-11-11
  • [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析2011

    • Author(s)
      好井健太朗、山崎翔子、持舘景太、苅和宏明、高島郁夫
    • Organizer
      第11回人と動物の共通感染症研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
  • [Presentation] 2008年北海道で分離されたダニ媒介性脳炎ウイルスOshima 08-AS株の病原性解析2011

    • Author(s)
      山崎翔子、好井健太朗、真田崇弘、苅和宏明、高島郁夫
    • Organizer
      第152回日本獣医学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解析2011

    • Author(s)
      好井健太朗、森藤可南子、永田典代、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
    • Organizer
      第152回日本獣医学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] ダニ媒介性脳炎ウイルスのE蛋白糖鎖は哺乳動物細胞におけるウイルス粒子分泌に影響する2011

    • Author(s)
      柳原なつみ、好井健太朗、石塚万里子、苅和宏明、高島郁夫
    • Organizer
      第152回日本獣医学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS2011

    • Author(s)
      Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
    • Organizer
      The 3rd International Young Researcher Seminar in Zoonosis Control 2011
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-16
  • [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS2011

    • Author(s)
      Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-15
  • [Presentation] ISOLATION AND CHARACTERIZATION OF TICK-BORNE ENCEPHALITIS VIRUS IN HOKKAIDO2011

    • Author(s)
      Yamazaki, S., Yoshii, K., Mottate, K., Murata, R., Sanada, T., Kariwa, H. and Takashima, I.
    • Organizer
      JAPAN IN 2008 : International Union of Microbiological Societies 2011
    • Place of Presentation
      Congress. Sapporo
    • Year and Date
      2011-09-15
  • [Presentation] ROLE OF THE N-LINKED GLYCAN OF ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS IN THE VIRUS REPLICATION AND PATHOGENICITY2011

    • Author(s)
      Yanagihara, N., Yoshii, K., Goto, A., Ikawa, A., Ishizuka, M., Kariwa, H. and Takashima I.
    • Organizer
      International Union of Microbiological Societies 2011
    • Place of Presentation
      Congress. Sapporo
    • Year and Date
      2011-09-15
  • [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスの作製とフラビウイルス抵抗性の解析2011

    • Author(s)
      好井健太朗、森藤可南子、永田典代、浅野淳、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
    • Organizer
      第46回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      金沢
    • Year and Date
      2011-05-20
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスを用いた病態発現機序の解析2011

    • Author(s)
      好井健太朗、寸田祐嗣、横澤香菜、苅和宏明、Michael R. Holbrook、高島郁夫
    • Organizer
      第15回日本神経ウイルス研究会
    • Place of Presentation
      金沢
    • Year and Date
      2011-05-19
  • [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築2010

    • Author(s)
      高野絢子、大森優紀、好井健太朗、横澤香菜、苅和宏明、高島郁夫
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析2010

    • Author(s)
      好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
  • [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病原性に与える影響の解析2010

    • Author(s)
      戸谷理詩、好井健太朗、村田亮、秋田紗希、田中智久、苅和宏明、梅村孝司、高島郁夫
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
  • [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査2010

    • Author(s)
      好井健太朗、持舘景太、大森優紀、千葉裕美子、真田崇弘、瀬戸隆弘、前田純子、小原真弓、安藤秀二、伊藤直人、杉山誠、佐藤浩、福島博、苅和宏明、高島郁夫
    • Organizer
      第10回人と動物の共通感染症研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-30
  • [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析2010

    • Author(s)
      山崎翔子、好井健太朗、持舘景太、村田亮、真田崇弘、苅和宏明、高島郁夫
    • Organizer
      第150回日本獣医学会
    • Place of Presentation
      帯広
    • Year and Date
      2010-09-16
  • [Presentation] ダニ媒介性脳炎ウイルスのE蛋白の糖鎖付加がウイルス性状に与える影響2010

    • Author(s)
      柳原なつみ、好井健太朗、後藤明子、伊川綾恵、石塚万里子、苅和宏明、高島郁夫
    • Organizer
      第150回日本獣医学会
    • Place of Presentation
      帯広
    • Year and Date
      2010-09-16
  • [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築2010

    • Author(s)
      高野絢子、大森優紀、好井健太朗、横澤香菜、苅和宏明、高島郁夫
    • Organizer
      第150回日本獣医学会
    • Place of Presentation
      帯広
    • Year and Date
      2010-09-16
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析2010

    • Author(s)
      好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
    • Organizer
      第150回日本獣医学会
    • Place of Presentation
      帯広
    • Year and Date
      2010-09-16
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析2010

    • Author(s)
      好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
    • Organizer
      第45回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-28
  • [Book] Tick-borne flavivirus2010

    • Author(s)
      Yoshii, K., Kariwa, H., Takashima, I.
    • Total Pages
      75-88
    • Publisher
      Animal viruses. Transworld research network
  • [Book] Hokkaido virus and its mode of infection among the gray red-backed vole, Myodes rufocanus2010

    • Author(s)
      Kariwa, H., Yoshii, K., Takashima I.(他9名. 9番目)
    • Total Pages
      23-46
    • Publisher
      Animal viruses. Transworld research network

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Published: 2013-07-31  

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