2011 Fiscal Year Final Research Report
Flavivirus-specific antiviral activity of 2'-5'-oligoadenylate synthetases
| Project/Area Number |
22780268
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHII Kentaro 北海道大学, 大学院・獣医学研究科, 助教 (50421988)
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| Research Collaborator |
TAKASHIMA Ikuo 北海道大学, 大学院・獣医学研究科, 名誉教授 (30002083)
KARIWA Hiroaki 北海道大学, 大学院・獣医学研究科, 准教授 (70224714)
AGUI Takashi 北海道大学, 大学院・獣医学研究科, 教授 (00212457)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 人獣共通感染症 |
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| Research Abstract |
The interferon-inducible 2'-5'-oligoadenylate synthetases(OAS) play important roles in the antiviral activity against RNA virus infection. The murine isoform Oas1b gene has been identified as a critical determinant for genetic susceptibility to flavivirus infection. In this study, we analyzed the mechanism of the flavivirus-specific antiviral activity of Oas1b, and indicated that OAS plays crucial roles in the pathogenesis of flavivirus.
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Research Products
(40 results)
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[Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS2011
Author(s)
Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
Organizer
The 3rd International Young Researcher Seminar in Zoonosis Control 2011
Place of Presentation
Sapporo
Year and Date
2011-09-16
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[Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS2011
Author(s)
Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo
Year and Date
2011-09-15
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[Presentation] ISOLATION AND CHARACTERIZATION OF TICK-BORNE ENCEPHALITIS VIRUS IN HOKKAIDO2011
Author(s)
Yamazaki, S., Yoshii, K., Mottate, K., Murata, R., Sanada, T., Kariwa, H. and Takashima, I.
Organizer
JAPAN IN 2008 : International Union of Microbiological Societies 2011
Place of Presentation
Congress. Sapporo
Year and Date
2011-09-15
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[Presentation] ROLE OF THE N-LINKED GLYCAN OF ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS IN THE VIRUS REPLICATION AND PATHOGENICITY2011
Author(s)
Yanagihara, N., Yoshii, K., Goto, A., Ikawa, A., Ishizuka, M., Kariwa, H. and Takashima I.
Organizer
International Union of Microbiological Societies 2011
Place of Presentation
Congress. Sapporo
Year and Date
2011-09-15
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