2011 Fiscal Year Final Research Report
Formulation studies on neuropeptides for type-2 diabetes treatment
| Project/Area Number |
22790043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ONOUE Satomi 静岡県立大学, 薬学部, 准教授 (00457912)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ドラッグデリバリー |
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| Research Abstract |
The present study aimed to develop new therapeutic agent to treat type 2 diabetes with a focus on glucagon-secretin family neuropeptides. Biochemical studies and structure-activity relationship studies were undertaken to provide new promising derivatives of neuropeptides. To improve therapeutic compliance for neuropeptides, sustained-release dry powder formulation system was also established with use of biodegradable polymer.
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[Journal Article] Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R15,20,21, L17, A24,25, des-N28]-VIP-GRR) in experimental asthma/COPD model rats.2011
Author(s)
Satomi Onoue, Yoshiki Aoki, Takuya Matsui, Yoshiki Kojo, Shingen Misaka, Takahiro Mizumoto, Shizuo Yamada
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Journal Title
IntJ Pharm
Volume: 410
Pages: 54-60
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[Journal Article] Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats.2010
Author(s)
Satomi Onoue, Shingen Misaka, Yosuke Aoki, Shinichiro Karaki, Atzukazu Kuwahara, Asami Ohide, Takahiro Mizumoto, and Shizuo Yamada
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Journal Title
Eur. J.Pharm. Sci.
Volume: 41
Pages: 508-514
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