2012 Fiscal Year Final Research Report
Elucidation of molecular mechanism for chemoresistance elicited by lipid peroxide-detoxifying enzymes.
| Project/Area Number |
22790074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌 / 還元酵素 / 抗癌剤 / 過酸化脂質 |
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| Research Abstract |
Up-regulation of aldo-keto reductase (AKR) 1B10 was provoked with resistance development of human colon cancer HT29 cells toward doxorubicin or mitomycin C. In addition, results in several experiments with the two resistant cancer cellssuggest that the high AKR1B10 expression contributes tomechanism(s) of the chemoresistance through facilitating the reductase activity toward the drugs and antioxidant activity. Furthermore, overexpression and inhibition of the enzyme in the non-resistant cells decreased and increased, respectively, susceptibility to cytotoxic effects of the drugs, raising the possibility that AKR1B10 is a predominant factor involved in gain of colon cancer chemoresistance.
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