2011 Fiscal Year Final Research Report
The role of long chain fatty acid : amino acid conjugation in insulin resistance
| Project/Area Number |
22790097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
ITO Takashi 兵庫医療大学, 薬学部, 助教 (80423119)
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| Project Period (FY) |
2010 – 2011
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| Keywords | インスリン抵抗性 / 脂質毒性 / 脂肪酸 / タウリン / アミノ酸 / タウリントランス |
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| Research Abstract |
We evaluated the impacts of taurine deficiency to high fat diet-induced pathology by using taurine transporter knockout mice. The present studies indicate that taurine deficiency improve high fat diet-induced glucose intolerance and insulin resistance. Moreover, our data suggest that taurine deficiency causes inefficient energy production in tissues, which results in the improvement against high fat diet-induced pathology.
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