2012 Fiscal Year Final Research Report
A novel potential mechanism for the transcriptional regulation by ABCA1
| Project/Area Number |
22790102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
OKUHIRA Keiichiro 国立医薬品食品衛生研究所, 機能生化学部, 主任研究官 (10425671)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脂質 / 動脈硬化 |
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| Research Abstract |
In this study, we investigated that the cleavage of C-terminal intracellular domain of ABCA1 and the nuclear translocation of the cleavage product. The inhibition of TLR3 signaling pathway decreased the cleavage of ABCA1. In HEK293 cells expressing the intracellular domain of ABCA1, dsRNA stimulation increased the translocation of intracellular domain into nuclear. These results indicate that TLR3 pathway is critical for the cleavage of ABCA1 and its nuclear translocation.
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