2011 Fiscal Year Final Research Report
Prediction of human drug metabolism using chimeric mice transplanted with human hepatocytes
| Project/Area Number |
22790109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
SANOH Seigo 広島大学, 大学院・医歯薬学総合研究科, 助手 (00552267)
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| Research Collaborator |
HORIGUCHI Aya 広島大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Keywords | ヒト肝細胞移植キメラマウス / 肝細胞 / 薬物代謝酵素 / 代謝物予測 |
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| Research Abstract |
The chimeric mice transplanted with human hepatocytes were used in this study. I selected some model compounds that are metabolized by several drug metabolic enzymes in liver and compared the profiles in humans to evaluate the utility of these mice for human prediction. These profiles in mice were approximately similar to those in humans. Thus, this model could be a good in vivo model for predicting drug metabolism and pharmacokinetics in humans during pre-clinical stage of pharmaceutical development.
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