2011 Fiscal Year Final Research Report
Development of design of antiviral drug by substitution of carbohydrate ligand for peptide
| Project/Area Number |
22790115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ペプチドドラッグ / ライブラリー / インフルエンザ / ヘマグルチニン / 感染阻害剤 / ファージ提示法 / 親和性選択 / 感染症 |
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| Research Abstract |
Influenza virus binds to carbohydrate receptors on the host cell surface at an initial step in the infection process. The method to design of peptide drug was developed based on the concept of substitution of carbohydrate ligand for peptide. The carbohydrate-mimetic peptides showed inhibitory activity for virus infection among multiple types of strain. Furthermore chemical modification of peptide with monosaccharide indicated that the peptides have the highest inhibitory activity. This resulted in the promising methodology for design of novel antiviral drugs.
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