2011 Fiscal Year Final Research Report
Research on pathological mechanism of amyloid beta peptide and application to the aggregation inhibitor
| Project/Area Number |
22790118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo (2011)
Kyoto Pharmaceutical University (2010) |
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Principal Investigator |
YOUHEI Sohma 東京大学, 大学院・薬学系研究科, 特任研究員 (10565518)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アミロイド / アルツハイマー病 / イソペプチド / ペプチド / 凝集 / 阻害剤 |
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| Research Abstract |
Studies with the O-acyl isopeptides of A〓 mutants and pyroGlu-A〓 enabled us to identify new functions of amyloid beta peptides. In addition, the O-acyl isopeptide of A〓1〓42 with an ester bond at the Gly25〓Ser26 moiety had a capability of inhibiting fibril formation of A〓1〓42 at equimolar ratio.
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Research Products
(21 results)
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[Journal Article] Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element.2011
Author(s)
Hironobu Hojo, Hidekazu Katayama, Chiharu Tano, Yuko Nakahara, Azusa Yoneshige, Junko Matsuda, Youhei Sohma, Yoshiaki Kiso, Yoshiaki Nakahara
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Journal Title
Tetrahedron Lett.
Volume: 52
Pages: 635-639
DOI
Peer Reviewed
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