2011 Fiscal Year Final Research Report
Development of a database to predict the pharmacokinetic changes and the clinical significance by drug-drug interactions and genetic polymorphism
| Project/Area Number |
22790147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHNO Yoshiyuki 東京大学, 医学部附属病院, 助教 (40553699)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 医療薬剤学 / 薬物間相互作用 |
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| Research Abstract |
Systematic survey was conducted to list and classify drugs involved in significant pharmacokinetic drug-drug interactions(DDIs). The results were updated every year and were reported in PharmaTribune journal which is distributed to all pharmacies in Japan. In this study, we further investigated a method to predict in vivo DDIs from in vitro experiments, and clarified contributions of intestinal metabolism in DDIs caused by inhibition of CYP3A4.
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