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2011 Fiscal Year Final Research Report

Development of screening method for albumin biomarker for personalized medicine

Research Project

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Project/Area Number 22790160
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionNagasaki University

Principal Investigator

OHYAMA Kaname  長崎大学, 大学院・医歯薬学総合研究科, 助教 (50437860)

Project Period (FY) 2010 – 2011
Keywords臨床化学
Research Abstract

Albumin with minor modification(i. e. Mercapto-albumin) are thought to be a target in fishing biomarker for several diseases and personalized medicine. A novel fluorescence probe specifically binding to human serum albumin and a polymer-monolithic capillary column for separation of the modified albumin were developed.

  • Research Products

    (10 results)

All 2012 2011 2010 Other

All Journal Article (4 results) Presentation (4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Monolithic poly(butyl methacrylate-ethylene dimethacrylate-methacrylic acid) column for capillary electrochromatography2011

    • Author(s)
      K. Ohyama, D. Horiguchi, N. Kishikawa, N. Kuroda
    • Journal Title

      Journal of Separation Science

      Volume: 34 Pages: 2279-2283

  • [Journal Article] Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis2011

    • Author(s)
      K. Ohyama, Y. Ueki, A. Kawakami, N. Kishikawa, M. Tamai, M. Osaki, S. Kamihira, K. Nakashima, N. Kuroda*
    • Journal Title

      Clinical Chemistry

      Volume: 57 Pages: 905-909

  • [Journal Article] Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector2010

    • Author(s)
      N. Kishikawa, K. Ohyama, J. Yao, A. Miyamoto, T. Imazato, Y. Ueki, K. Nakashima, E. Maehata, N. Kuroda*
    • Journal Title

      Clinica Chimica Acta

      Volume: 411 Pages: 1111-1115

  • [Journal Article] A toxicoproteomic study on cardioprotective effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity2010

    • Author(s)
      K. Ohyama, M. Tomonari, T. Ichibangase, H. To, N. Kishikawa, K. Nakashima, K. Imai, N. Kuroda
    • Journal Title

      Biochemical Pharmacology

      Volume: 80 Pages: 540-547

  • [Presentation] 早期関節リウマチ患者のイムノコンプレキソーム解析2012

    • Author(s)
      大山要, 馬場雅子, 川上純, 玉井慎美, 岸川直哉, 植木幸孝, 上平憲, 中島憲一郎, 黒田直敬
    • Organizer
      第23回日本臨床化学会九州支部総会
    • Place of Presentation
      福岡
    • Year and Date
      20120200
  • [Presentation] 慢性関節リウマチ患者血清のLC-MS/ MSによるイムノコンプレキソーム解析2011

    • Author(s)
      大山要, 植木幸孝, 川上純, 岸川直哉, 上平憲, 中島憲一郎, 黒田直敬
    • Organizer
      第18回クロマトグラフィーシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      20110600
  • [Presentation] メタクリル酸をイオン性モノマーとするCEC用モノリスカラムの評価2010

    • Author(s)
      大山要, 堀口大輔, 岸川直哉, 中島憲一郎, 黒田直敬
    • Organizer
      第21回クロマトグラフィー科学会議
    • Place of Presentation
      西宮
    • Year and Date
      20101000
  • [Presentation] Characterization of peptide chiral selectors prepared by solid-phase synthesis in HPLC enantioseparation2010

    • Author(s)
      K. Ohyama, K. Oyamada, N. Kishikawa, Y. Ohba, M. Wada, K. Nakashima, N. Kuroda
    • Organizer
      22^〈th〉International Symposium on Chirality
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20100700
  • [Remarks]

    • URL

      http://www.ph.nagasaki-u.ac.jp/lab/analysis/index-j.html

  • [Patent(Industrial Property Rights)] 免疫複合体の網羅的解析方法および新規関節リウマチバイオマーカー2011

    • Inventor(s)
      黒田直敬,大山要,岸川直哉
    • Industrial Property Rights Holder
      国立大学法人長崎大学
    • Industrial Property Number
      特許,特願2011-215402
    • Filing Date
      2011-09-29

URL: 

Published: 2013-07-31  

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