2012 Fiscal Year Final Research Report
Development of Nitric oxide traffic protein as a novel drug againstischemic diseases
| Project/Area Number |
22790162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHIMA Yu 熊本大学, 薬学部, 助教 (00457590)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬物動態学 / ドラッグデリバリーシステム |
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| Research Abstract |
S-Nitrosated human serum albumin (SNO-HSA) is useful in preventing liverischemia/reperfusion injury, and SNO-HSA should thus be able to prevent cell injury duringliver transplantation. However, the potential protective effect of SNO-HSA on acombination of cold and warm ischemia, which is obligatory when performing livertransplantation, has not been examined. Our results indicate that a combination of SNO-HSAand UW solution can be used to prevent the two types of ischemia. Therefore, SNO-HSA-addedUW solution could be very useful in transplantation, because the previously imposedconstraints on preservation time can be removed. This is a great advantage in a situationas the present one with increased utilization of scarce donor organs for more recipients
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[Journal Article] p-Cresyl sulfate causes renaltubular cell damage by inducingoxidative stress by activation ofNADPH oxidase2013
Author(s)
Watanabe H, Miyamoto Y,Honda D, Tanaka H, Wu Q, Endo M,Noguchi T, Kadowaki D, Ishima Y,Kotani S, Nakajima M, Kataoka K,Kim-Mitsuyama S, Tanaka M, FukagawaM, Otagiri M, Maruyama T.
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Journal Title
Kidney Int
Volume: 83
Pages: 582-92.
Peer Reviewed
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[Journal Article] A human serum albumin-thioredoxinfusion protein preventsexperimental contrast-inducednephropathy2013
Author(s)
Kodama A, Watanabe H, TanakaR, Tanaka H, Chuang VT, Miyamoto Y,Wu Q, Endo M, Hamasaki K, Ishima Y,Fukagawa M, Otagiri M, Maruyama T.
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Journal Title
Kidney Int
Volume: 83
Pages: 446-54.
Peer Reviewed
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[Journal Article] S-nitrosated α-1-acidglycoprotein kills drug-resistantbacteria and aids survival in sepsis2013
Author(s)
WatanabeK, Ishima Y, Akaike T, Sawa T, KurodaT, Ogawa W, Watanabe H, Suenaga A,Kai T, Otagiri M, Maruyama T.
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Journal Title
FASEB J
Volume: 27
Pages: 391-8.
Peer Reviewed
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[Journal Article] Hirata K, Maruyama T,Watanabe H, Ishima Y, Hashida M,Otagiri M.2010
Author(s)
Katayama N, Nakajou K, Ishima Y, IkutaS, Yokoe JI, Yoshida F, Suenaga A,Maruyama T, Kai T, Otagiri M.
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Journal Title
Nitric Oxide
Volume: 22
Pages: 259-265.
Peer Reviewed
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[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用2012
Author(s)
渡辺佳織 1, 異島 優 1, 2, 赤池孝章 3,澤 智裕 3, 黒田照夫 4, 小川和加野 4, 渡邊博志 1, 2, 甲斐俊哉 1, 5, 小田切優樹 1, 6, 7, 丸山徹 1, 2
Organizer
第12回日本 NO 学会学術集会
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
20120629-30
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[Presentation] p-Cresyl sulfate causes renal tubularcell damage by inducing oxidativestress through the activation of NADPHoxidaseHiroshi2012
Author(s)
Hiroshi Watanabe1,2, Daisuke Honda1,Yohei Miyamoto1, Tsuyoshi Noguchi1,Daisuke Kadowaki1,2, Yu Ishima1,2,Motoko Tanaka3, Hisae Tanaka4,Masafumi Fukagawa4, Masaki Otagiri1,5and Toru Maruyama1,2
Organizer
49th ERA-EDTA Congress, Paris 2012
Place of Presentation
Paris(France)
Year and Date
20120524-27
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[Presentation] A uremic toxin,3-carboxy-4-methyl-5-propyl-2-furanpropionate accumulates inproximal tubular cells and inducescell damage through increasingoxidative stress2012
Author(s)
Yohei Miyamoto1, Yasunori Iwao2,Katsumi Mera1, Hiroshi Watanabe1,3,Daisuke Kadowaki1,3, Yu Ishima1,Victor Tuan Giam Chuang4, KeizoSato5, Masaki Otagiri1.6 and ToruMaruyama1,3*
Organizer
49th ERA-EDTACongress, Paris 2012
Place of Presentation
Paris(France)
Year and Date
20120524-27
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