2012 Fiscal Year Final Research Report
Investigation of the mechanism of TRP channel mediated by a lipid mediator, 2ccPA, via LPA receptor
| Project/Area Number |
22790203
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Ochanomizu University |
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Principal Investigator |
GOTOH Mari お茶の水女子大学, サイエンス&エデュケーションセンター, 研究協力員 (80467050)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 環状ホスファチジン酸 / 生理活性脂質 |
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| Research Abstract |
We have been indicated that cyclic phosphatidic acid, cPA, and its derivative, 2ccPA, are potent inhibitors of nociceptive transmission by C-primary afferents, and reverse inflammatory and neuropathic pain. In this research, we aimed to clarify the molecular mechanism of analgesic function of cPA and 2ccPA. We found that the activation of LPA5 receptor by 2ccPA does not affect the activation of TRPV1. Therefore, we are going to examine the effect of 2ccPA on the other TRP channel activation.
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