2011 Fiscal Year Final Research Report
The role of opioid neurotransmission in pain-induced aversion
| Project/Area Number |
22790239
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
IDE Soichiro 北海道大学, 大学院・薬学研究院, 助教 (30389118)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 痛み / 嫌悪 / 不安 / 食欲 / 分界条床核 / オピオイド / ノルアドレナリン |
|---|
| Research Abstract |
In the present study, we examined the role of the opioid within the bed nucleus of the stria terminalis(BNST) in pain-induced aversion. The conditioned place aversion(CPA) induced by intra-dorsolateral part of BNST(dlBNST) injection of CRF was reversed by the co-injection of an opioid agonist. On the other hand, nociceptive behaviors induced by pain stimulus were also changed by intra-dlBNST injection of opioid agonist. Further, we revealed that noradrenergic transmission within the ventral part of BNST regulates food intake and anxiety-like behaviors.
|
