A study on the anti-obesity function of an adipokine, D-dopachrome tautomerase

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790253
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: The University of Tokushima
• Principal Investigator: IWATA Takeo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10350399)
• Project Period (FY): 2010 – 2011
• Keywords: アディポカイン / 肥満 / 脂肪組織 / インスリン抵抗性 / 脂質代謝

Research Abstract

D-dopachrome tautomerase whose mRNA levels are decreased in obese adipocytes acts to regulate contents of triacylglycerol in adipocytes. In this study, DDT was found to regulate expression and activity of molecules involved in lipid metabolism in adipocytes. Furthermore, administration of DDT improved the glucose intolerance in obese mice. These results suggested that DDT acts as an adipokine with anti-obese property.

Research Products

• [Journal Article] The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism (2012)
  • Author(s): Iwata T, Taniguchi H, Kuwajima M, Taniguchi T, Okuda Y, Sukeno A, Ishimoto K, Mizusawa N, Yoshimoto K
  • Journal Title: PLos One Volume: 7 Pages: e33402
  • DOI: DOI:10.1371/journal.pone.0033402
  • Peer Reviewed
• [Journal Article] Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking (2011)
  • Author(s): Hirata Y, Hosaka T, Iwata T, Le CT, Jambaldorj B, Teshigawara K, Harada N, Sakaue, H, Sakai T, Yoshimoto K, Nakaya Y
  • Journal Title: Biochem Biophys Res Commun Volume: 405 Pages: 96-101
  • DOI: DOI:10.1016/j.bbrc.2010.12.134
  • Peer Reviewed
• [Presentation] D-dopachrome tautomeraseは肥満マウスでのインスリン抵抗性を改善する (2011)
  • Author(s): 岩田武男
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場(岐阜市)
  • Year and Date: 20110930-1002
• [Presentation] D-dopachrome tautomeraseは脂肪細胞での脂質代謝を制御する (2011)
  • Author(s): 岩田武男
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌プリンスホテル(札幌市)
  • Year and Date: 20110519-21
• [Presentation] Functional analysis of a novel adipokine, D-dopachrome tautomerase, in preadipocytes (2010)
  • Author(s): 石本恭子
  • Organizer: International Joint Symposium : The University of Tokushima, Universitas Gadjah Mada, Niigata University
  • Place of Presentation: The Patra Bali(インドネシアバリ)
  • Year and Date: 20101217-18
• [Presentation] D-dopachrome tautomeraseは脂肪細胞での中性脂肪量を制御する (2010)
  • Author(s): 岩田武男
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20100920-22
• [Presentation] D-dopachrome tautomeraseが脂肪分化に及ぼす影響 (2010)
  • Author(s): 石本恭子
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20100920-22