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2011 Fiscal Year Final Research Report

Analysis for physiological role of the Ca2+-binding ER protein calumin

Research Project

  • PDF
Project/Area Number 22790288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

YAMAMOTO Shinichiro  京都大学, 大学院・薬学研究科, 助教 (10542102)

Project Period (FY) 2010 – 2011
Keywords小胞体 / Ca^<2+>
Research Abstract

Calumin is transmembrane protein on endoplasmic reticulum. Although calumin knockout in mice is embryonic lethal around E10. 5-11. 5, the physiological role is no clear. Thus, we investigated the physiological role of calumin. Calumin is specifically expressed in yolk sac endoderm cells which are the principal nutrient-transporting cells. Additionally, lipid droplets are accumulated in calumin knockout yolk sac endoderm cells. Therefore, it was suggested that calumin was involved in lipid transport in endoderm cells.

  • Research Products

    (3 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death2012

    • Author(s)
      Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K, Mori Y.
    • Journal Title

      Cell Calcium.

      Volume: 51 Pages: 179-185

    • DOI

      DOI:10.1016/j.ceca.2011.12.011

    • Peer Reviewed
  • [Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011

    • Author(s)
      Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, &
    • Journal Title

      Cell Metabolism

      Volume: 14 Pages: 231-2413

    • DOI

      DOI:10.1016/j.cmet.2011.05.011

    • Peer Reviewed
  • [Journal Article] TRPA1 underlies a sensing mechanism for O_22011

    • Author(s)
      Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y.
    • Journal Title

      Nature Chemical Biology

      Volume: 10 Pages: 701-711

    • DOI

      DOI:10.1038/nchembio.640

    • Peer Reviewed

URL: 

Published: 2013-07-31  

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