2011 Fiscal Year Final Research Report
Molecular mechanism of the spontaneous regression of neuroblastoma
| Project/Area Number |
22790309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INOUE Jun 東京医科歯科大学, 難治疾患研究所, 助教 (50568326)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経芽腫 / 自然退縮 / 細胞死 / タンパク質分解 / ユビキチン |
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| Research Abstract |
It is unknown for the molecular mechanism of spontaneous regression of neuroblastoma(NB). I have previously demonstrated that the cell death mediated by accumulation of LAPTM5(lysosomeal-associated protein multispanning membrane 5) protein was closely associated with tumor regression of NBs. With the support of this grant, I clarified the mechanism of transcriptional and post-translational regulation for the expression, and suggested that the dysregulation of its mechanism may LAPTM5-mediated cell death in NB cells.
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Research Products
(8 results)
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[Presentation] Lysosomal-associated protein multispanning transmembrane 5 gene(LAPTM5) is associated with spontaneous regression of neuroblastomas2010
Author(s)
Inoue J, Misawa A, Tanaka Y, Ichinose S, Sugino Y, Hosoi H, Sugimoto T, Imoto I, Inazawa J
Organizer
101th annual meeting of American Association for Cancer Research 2010
Place of Presentation
Washington, DC, USA
Year and Date
20100417-21
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