2011 Fiscal Year Final Research Report
Roles of leukotriene receptor signaling in cell proliferation
| Project/Area Number |
22790320
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SAEKI Kazuko 九州大学, 大学院・医学研究院, 助教 (00553273)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生理活性脂質 / GPCR / 病態モデル |
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| Research Abstract |
BLT2 is a receptor for LTB_4 and 12-HHT and expressed on the epithelium of skin and intestine. To clarify the role of BLT2 in these tissues, the models of inflammatory colitis, tumorigenesis in the colon, and skin wound healing were performed. It was revealed that BLT2 suppresses inflammatory colitis and tumorigenesis in the colon and promotes skin wound healing.
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[Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis2010
Author(s)
Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, Yokomizo T
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Journal Title
FASEB J
Volume: 24(12)
Pages: 4678-4690
DOI
Peer Reviewed
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