2011 Fiscal Year Final Research Report
Analysis for the signal crosstalk of growth factor during epithelial-mesenchymal transition(EMT)
| Project/Area Number |
22790323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUZUKI Kentaro 熊本大学, 発生医学研究所, 助教 (20404345)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 上皮間葉転換 / Epithelial-Mesenchymal Transition(EMT) / Wnt/b-catenin / Bmp(Bone morphogenetic protein) |
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| Research Abstract |
To understand the molecular mechanisms of the Epithelial-Mesenchymal Transition(EMT) by Wnt/・-catenin signaling pathway, we analyzed the embryonic skin of K5-Cre Catnb^<(ex3) fl/+> mice. Expression of Snail, one of the EMT induce factors, was increased in K5-Cre Catnb^<(ex3) fl/+> mice. In addition to the snail, Bone morphogenetic protein(Bmp) signaling was activated in the mutant mice. Interestingly, double compound mutant mice with BmprIA, K5-Cre Catnb^<(ex3) fl/+> BmprIA^<fl/fl> DKO mice, showed the accelerated EMT. These results suggest that Wnt/・-catenin signaling may act not only as the EMT-activator but also as the EMT-repressor through the Bmp signaling.
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[Journal Article] Retinoic acid signaling regulates Sonic hedgehog and Bone morphogenetic protein signalings during genital tubercle development2012
Author(s)
Liu L., Suzuki K., Nakagata N., Mihara K., Matsumaru D., Ogino Y., Yashiro K., Hamada H., Liu Z., Evans S., Mendelsohn M., Yamada G
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Journal Title
Birth Defects Research Part B : Developmental and Reproductive Toxicology
Volume: 95(1)
Pages: 79-88
Peer Reviewed
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