2011 Fiscal Year Final Research Report

The effect of XMRV-infection on the malignancy of tumor cells

Research Project

Project/Area Number	22790427
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Virology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	SAKUMA Ryuta 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50547429)
Project Period (FY)	2010 – 2011
Keywords	病原性 / XMRV
Research Abstract	XMRV is a newly identified human gamma-retrovirus cloned from a prostate cancer tissue sample. Since there was no evidence to show that XMRV infection could be a possible trigger of prostate cancer generation, we assessed if XMRV-infection increased tumor malignancy. Both the anchorage dependency of tumor cells and a cell growth efficacy under lower serum concentration was not affected by XMRV infection. Then we concluded that XMRV infection did not affect a tumor malignancy. These data agreed with some other reports published from our group and others, recently.