2011 Fiscal Year Final Research Report
Function of claudins in Aire-expressing medullary thymic epithelial cells
| Project/Area Number |
22790458
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HAMAZAKI Yoko 京都大学, 医学研究科, 准教授 (10362477)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | T細胞分化 / 胸腺 / 自己免疫疾患 / 胸腺上皮細胞 / クローディン / Aire |
|---|
| Research Abstract |
To investigate the function of claudin (Cld)-3, 4 in thymic epithelial cells, we first madesingle KO mice for each gene. There was no obvious defect in each single KO mice; thus we next tried to make double KO mice. Since the distance of each gene on genome is only 40Kbp, we made a strategy in which Cld3 Tg vector was introduced into Cld4KO ES cells. We have succeded in making double KO mice and now are analyzing the phenotypes on thymic organogenesis and T cell development.
|
Research Products
(19 results)
-
-
-
[Journal Article] SPA-1 controls the invasion and metastasis of human prostate cancer2011
Author(s)
Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada N, Kobayashi T, Toda Y, Yamasaki T, Inoue TA, Kajita Y, Maeno A, Kamba T, Mikami Y, Kamoto T, Yamada T, Kanno T, Yoshikawa K, Ogawa O, Minato N, Nakamura E
-
Journal Title
Cancer Sci.
Volume: 102(4)
Pages: 828-36
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
