2011 Fiscal Year Final Research Report
Regulation of autoimmune response by an Ig domain-containing sialomucin, nepmucin
| Project/Area Number |
22790466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
UMEMOTO Eiji 大阪大学, 医学系・研究科, 助教 (90452440)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫寛容・自己免疫 / 高内皮性静脈 / リンパ球トラフィッキング |
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| Research Abstract |
Nepmucin is an Ig-domain-containing adhesion molecule expressed in certain types of vascular endothelial cells and promotes lymphocyte transendothelial migration in vitro. We found that nepmucin binds to phosphatidylserine, which appears on the outer leaflet of the plasma membrane in apoptotic cells. Nepmucin promotes the uptake of apoptotic cells by endothelial cells of lymph node high endothelial venule. Nepmucin-deficient mice showed elevated autoantibody production in an age-dependent manner. Collectively, our findings indicate that nepmucin is involved in autoimmune response.
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[Journal Article] Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7-and CXCR4-mediated signaling2012
Author(s)
*Umemoto E., * Otani K., Ikeno T., Garcia N. V., Hayasaka H., Bai Z., Jang M. H., Tanaka T., Nagasawa T., Ueda K., & Miyasaka M.(* equal contribution)
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Journal Title
J. Immunol
Volume: (In press)
Peer Reviewed
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[Journal Article] SIRPτ/ CD172a Regulates Eosinophil Homeostasis2011
Author(s)
Garcia N. V., Umemoto E., Saito Y., Yamasaki M., Hata E., Matozaki T., Murakami M., Jung Y. J., Woo S. Y., Seoh J. Y., Jang M. H., Aozasa K., & Miyasaka M.
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Journal Title
J. Immunol
Volume: 187
Pages: 2268-2277
Peer Reviewed
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