Immunoregulation and therapeutic application of IL-17-producing gamm delta T cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790468
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Kyushu University
• Principal Investigator: SHIBATA Kensuke 九州大学, 生体防御医学研究所, 助教 (50529972)
• Project Period (FY): 2010 – 2012
• Keywords: 粘膜免疫 / IL-17産生gd T細胞

Research Abstract

IL-17-producing gd T cells are involved in not only host defense against pathogens but also pathogenesis of various autoimmune diseases. We found that Notch-Hes1 pathway is critically involved in the development of IL-17-producing gd T cells. Furthermore, in infection mouse model with an opportunistic fungi, Candida albicans, IL-17-producing gd T cells had a protective role in the early stage of host defense by inducing neutrophil infiltration. Thus, our study provides a novel insight of development and function of IL-17-producing gd T cells.

Research Products

• [Journal Article] Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells (2013)
  • Author(s): Sakuraba K, Shibata K, Iwamoto Y, Yoshikai Y, Yamada H
  • Journal Title: J Immunol Volume: 190 Pages: 1560-6
  • Peer Reviewed
• [Journal Article] Innate memory phenotype CD4+ T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner (2011)
  • Author(s): Umeda K, Sun X, Guo Y, Yamada H, Shibata K, Yoshikai Y.
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 645-56
  • Peer Reviewed
• [Journal Article] IL-17 production by gammadelta T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guerin treatment against bladder cancer (2011)
  • Author(s): Takeuchi A, Dejima T, Yamada H, Shibata K, Nakamura R, Eto M, Nakatani T, Naito S, Yoshikai Y.
  • Journal Title: Eur J Immunol Volume: 41 Pages: 246-51
  • Peer Reviewed
• [Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing gammadelta T cells (2011)
  • Author(s): Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.
  • Journal Title: Blood Volume: 118 Pages: 586-93
  • Peer Reviewed
• [Journal Article] The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice (2011)
  • Author(s): Fuchiwaki T, Sun X, Fujimura K, Yamada H, Shibata K, Muta H, Podack ER, Kawauchi H, Yoshikai Y.
  • Journal Title: Eur J Immunol Volume: 41 Pages: 2947-54
  • Peer Reviewed
• [Journal Article] Protective role of naturally occurring interleukin-17A-producing gammadelta T cells in the lung at the early stage of systemic candidiasis in mice (2011)
  • Author(s): Dejima T, Shibata K, Yamada H, Hara H, Iwakura Y, Naito S, Yoshikai Y
  • Journal Title: Infect Immun Volume: 79 Pages: 4503-10
  • Peer Reviewed
• [Journal Article] CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice (2010)
  • Author(s): Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Yoshikai Y.
  • Journal Title: J Immunol Volume: 185 Pages: 2222-30
  • Peer Reviewed
• [Journal Article] CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses (2010)
  • Author(s): Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Iwakura Y, Yoshikai Y
  • Journal Title: J Immunol Volume: 185 Pages: 7671-80
  • Peer Reviewed
• [Presentation] Notch-RBP-Jκ-IL-7 receptor alpha axis is essential for the maintenance of IL-17-producing γδ T cells (2012)
  • Author(s): 柴田健輔
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸, 日本
  • Year and Date: 2012-12-07
• [Presentation] Intrathymic programming of murine gd T cells by Notch signaling (2012)
  • Author(s): 柴田健輔
  • Organizer: gd T cell conference
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2012-06-01
• [Presentation] IL-7-receptor-α-mediated signaling is required for the development of naturally occurring IL-17-producing γδ T cells in the adult thymus (2011)
  • Author(s): 中村真隆、柴田健輔
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉, 日本
  • Year and Date: 2011-11-27
• [Presentation] The Basic Helix-Loop-Helix protein HES1 controls the differentiation of naturally occurring interleukin (IL)-17-producing γδ T cells (2010)
  • Author(s): 柴田健輔
  • Organizer: 14th International Congress Of Immunology
  • Place of Presentation: 神戸、日本
  • Year and Date: 2010-08-27
• [Presentation] The Basic Helix-Loop-Helix protein HES1, is required for the differentiation of naturally occurring interleukin(IL)-17-producing gd T cells (2010)
  • Author(s): 柴田健輔
  • Organizer: gd T cell conferenc
  • Place of Presentation: Kiel, Germany
  • Year and Date: 2010-05-19
• [Book] IL-17産生gd T細胞の分化と活性化 (2012)
  • Author(s): 柴田健輔
  • Total Pages: 5
  • Publisher: 臨床免疫・アレルギー科