2011 Fiscal Year Final Research Report
Drug utilization study and safety evaluation based on prediction approach for drug interactions in chemotherapy
| Project/Area Number |
22790511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 医薬品副作用・相互作用 / がん化学療法 / 漢方薬 |
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| Research Abstract |
The aim of this study was to describe utilization of anticancer drugs and concomitant medicines including Kanpo medicines, and evaluate safety of concomitant Kampo medicines in chemotherapy. As a result, Co-administration of Daikenchuto or Hangeshashinto, in patients treated with paclitaxel or irinotecan, respectively, showed significant association with decrease of platelet count over grade 3 based on Common Terminology Criteria for Adverse Events v4. 0 criteria. In addition, some of co-administrated Kampo medicines could affect occurrence of adverse effects, such as myelosuppression, electrolyte abnormality, or hepatic dysfunction.
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