2011 Fiscal Year Final Research Report
Development of transdermal patch of zoledroante for the treatment of bone metastasis
| Project/Area Number |
22790513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
YAMAMOTO Akira 京都薬科大学, 薬学部, 教授 (00166779)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ドラッグデリバリー |
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| Research Abstract |
Bisphosphonates are widely used for the treatment of bone diseases. In this study, we successfully developed a novel transdermal patch of zoledronate, a nitrogen-containing bisphosphonate, for the treatment of bone metastasis. The zoledronate patch effectively reduced the number of tumor cells in the bone in model mice with bone metastasis.
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[Journal Article] Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate : evaluation of transdermal absorption, safety and pharmacological effects after application in rats2012
Author(s)
Hidemasa Katsumi, Shu Liu, Yutaro Tanaka, Kaori Hitomi, Rie Hayashi, Yuka Hirai, Kosuke Kusamori, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
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Journal Title
Journal of Pharmaceutical Scicences
DOI
Peer Reviewed
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