Genetic and epigenetic differences in cholesterol kinetics in relation to NASH development between SHRSP and SHRSP5/Dmcr rat

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790543
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Nagoya University
• Principal Investigator: NAITO Hisao 名古屋大学, 大学院・医学系研究科, 助教 (90547556)
• Project Period (FY): 2010 – 2011
• Keywords: 肝線維化 / 非アルコール性脂肪性肝疾患 / コレステロール / 胆汁酸

Research Abstract

This study aims to clarify the differences in molecular mechanisms of the cholesterol and bile acid kinetics in the progression of high fat-cholesterol diet(HFC)-induced steatohepatitis and fibrosis between SHRSP5/Dmcr and SHRSP rats. In the result, SHRSP5/Dmcr may be more susceptible to liver fibrosis than SHRSP, which may be resulted from the higher intracellular accumulation of cytotoxic bile acid by decreased BSEP expression, though increased MRP3.

Research Products

• [Journal Article] Modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid under severe fibrosis progression in SHRSP5/Dmcr (2012)
  • Author(s): Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y, Nakajima T
  • Journal Title: Life Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat (2012)
  • Author(s): Moriya T, Kitamori K, Naito H, Yanagiba Y, Ito Y, Yamagishi N, Tamada H, Jia X, Tsuchikura S, Ikeda K, Yamori Y, Nakajima T
  • Journal Title: Environ Health Prev Med
  • Peer Reviewed
• [Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr (2011)
  • Author(s): Kitamori K, Naito H, Tamada H, Kobayashi M, Miyazawa D, Yasui Y, Sonoda K, Tsuchikura S, Yasui N, Ikeda K, Moriya T, Yamori Y, Nakajima T
  • Journal Title: Environ Health Prev Med
  • Peer Reviewed
• [Presentation] 高脂肪食摂取による2系統ラットの線維化進展の差は各々の胆汁酸排泄の違いと関連する (2012)
  • Author(s): 内藤久雄
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] 2系統のラットを用いた高脂肪食による肝炎・線維化進展に関連するコレステロール・胆汁酸動態の解析 (2011)
  • Author(s): 内藤久雄
  • Organizer: 第84回日本産業衛生学会学術総会
  • Place of Presentation: 東京都立産業貿易センター浜松町館
  • Year and Date: 2011-05-18
• [Presentation] 高脂肪食によるコレステロール・胆汁酸の体内動態変化と肝線維化進展への影響 (2011)
  • Author(s): 内藤久雄
  • Organizer: 第81回日本衛生学会学術総会
  • Year and Date: 2011-03-26
• [Presentation] Apoptosis and necrosis in relation to liver fibrosis in SHRSP5/Dmcr rats fed high-fat-cholesterol(HFC) diet and EPA effects (2011)
  • Author(s): Yetti H
  • Organizer: 第10回分子予防環境医学研究会
  • Place of Presentation: 京都府立医科大学医学部旧図書館棟3階講堂
  • Year and Date: 2011-01-22
• [Presentation] Differential Response to High-fat and High-cholesterol Diet-induced Hepatic Fibro genesis in SHRSP5/Dmcr and SHRSP Rats (2010)
  • Author(s): Naito H
  • Organizer: The Nine JSH Single Topic Conference NASH 2010
  • Place of Presentation: Grand Prince Hotel Takanawa
  • Year and Date: 20101118-19
• [Presentation] 高脂肪食による肝炎・繊維化進展におけるコレステロール・胆汁酸の合成・代謝・排泄に関わる核内受容体及び薬物トランスポーターの発現低下 (2010)
  • Author(s): 柳場由絵
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: フェニックス・プラザ(福井)
  • Year and Date: 20100526-28
• [Presentation] 2系統のラットを用いた高脂肪食による肝炎・線維化進展に関連するコレステロール・胆汁酸動態の解析 (2010)
  • Author(s): 内藤久雄
  • Organizer: 平成22年度日本産業衛生学会東海地方会学会
  • Place of Presentation: 浜松医科大学
  • Year and Date: 2010-11-13
• [Presentation] 高脂肪食によるコレステロール・胆汁酸の体内動態変化と肝線維化進展への影響 (2010)
  • Author(s): 内藤久雄
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-11