2011 Fiscal Year Final Research Report
Effects of environmental chemicals on the hematopoiesis of iPS cells
| Project/Area Number |
22790552
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
ITO Tomohiro 独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (60391067)
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| Project Period (FY) |
2010 – 2011
|
| Keywords | iPS細胞 / 造血幹細胞 / フタル酸エステル |
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| Research Abstract |
By using iPS cells, effects of phthalate esters on the hematopoiesis were examined. In that system, DEHP suppressed the appearance of hematopoietic progenitor from iPS cells while MEHP, a metabolite of DEHP, accelerated it. It was also suggested that their effects are caused independently of estrogen receptor and peroxisome proliferators-activated receptor.
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