2011 Fiscal Year Final Research Report
Relationship between the nucleotide substitution rate of the hepatitis C virus and the effects of interferon therapy in children.
| Project/Area Number |
22790622
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagoya City University |
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Principal Investigator |
ITO Koichi 名古屋市立大学, 大学院・医学研究科, 助教 (00444977)
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| Project Period (FY) |
2010 – 2011
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| Keywords | HCV / 遺伝子 / NS5B / IFN / 母子感染 |
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| Research Abstract |
Seven children infected by hepatitis C virus were treated with PEG-IFNα-2a at a dose of 90-180μg/kg s. c., once a week for 24-48 weeks. Six patients completed the treatment. One patient discontinued the treatment at 12 weeks. RVR was achieved in 2(29%) of the 7 patients. EVR was achieved in 7(100%) of the 7 patients. SVR was achieved in 6(86%) of the 7 patients. We isolated HCV-RNA from the sera of 7 children and analyzed the NS5b region. The nucleotide sequences in the NS5b region of HCV obtained from each of the children under treatment were identical to those of before treatment.
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