2012 Fiscal Year Final Research Report
Cell-type-specific role of STAT3 in non-alcoholic steathepatitis
| Project/Area Number |
22790631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 非アルコール性脂肪性肝炎 / STAT3 / メチオニンコリン欠乏食 / 細胞特異 |
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| Research Abstract |
The cell type specific role of STAT3 was examined by using hepatocyte-specific STAT3 knockout mice and macrophage/neutrophil specific STAT3 knockout mice. Both knockout mice and control wild type mice were fed with methionine-choline deficient diet, which is a murine NASH model. We have shown activation of STAT3 in hepatocyte prevents steatosis by inhibiting SREBP1c activation. On the other hand, we have revealed activation of STAT3 in macrophage/neutrophil accelerates inflammation in the liver, while it prevents steatosis by STAT3 activation in hepatocytes.
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