2011 Fiscal Year Final Research Report
A study of liver regeneration and new treatment of hepatocellular carcinoma based on the understanding of hepatic stem/progenitor cells for building a base and development.
| Project/Area Number |
22790634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肝再生 / 肝細胞癌 / SDF-1 / NCAM |
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| Research Abstract |
In this study, we got the following two conclusions. One is that by using knockout mice of CXCR4, the receptor of SDF-1, we elucidated that SDF-1 that is produced by hepatic stem/progenitor cells is important during liver regeneration. The other is that we firstly detected hepatocellular carcinamo(HCC) with hepatic stem/progenitor cell marker NCAM and revealed that prognosis of these NCAM-positive HCC was very poor.
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[Journal Article] Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence2012
Author(s)
Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y.
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Journal Title
J. Hepatol
Volume: 56(2)
Pages: 381-8
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[Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice
Author(s)
Tsuchiya A, Imai M, Kamimura H, Takamura M, Yamagiwa S, Sugiyama T, Nomoto M, Heike T, Nagasawa T, Nakahata T, Aoyagi Y
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Journal Title
Dig Dis Sci
Volume: (in print)
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