2011 Fiscal Year Final Research Report
B cell modulation by TLR9 and discovery of novel treatment in inflammatory bowel disease
| Project/Area Number |
22790657
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
KATAKURA Kyoko 福島県立医科大学, 医学部, 講師 (70423788)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 炎症性腸疾患 / Toll-like receptor / 制御性B細胞 |
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| Research Abstract |
We investigated whether TLR9 agonist CpG DNA protects mice from colonic inflammation through activated plasmacytoid dedritic cells(pDCs) and B cell proliferation. Administration of CpG DNA significantly suppressed colonic inflammation of DSS-induced colitis, and we could detect production of regulatory cytokines in mesenteric lymph nodes. Although we could not detect regulatory B cells as well as its induction by co-cultured with CpG DNA stimulated pDC. These results suggest that B cells, especially regulatory B cells didn' t concerned to protective effect of CpG DNA to mouse DSS colitis.
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