2011 Fiscal Year Final Research Report
Role of regulatory T cells and inflammatory macrophage/Kupffer cells in non-alcoholic steatohepatitis
| Project/Area Number |
22790659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 非アルコール性脂肪性肝炎 / 制御性T細胞 / NASH / Treg / クッパー細胞 / 炎症性マクロファージ / 肝免疫 |
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| Research Abstract |
We investigated numbers and function of regulatory T cells(Tregs) in liver tissue in mouse model for metabolic syndrome. We found that the numbers of Tregs in KK-Ay mice were increased, whereas the numbers of Tregs in ob/ob mice and db/db mice were not increased compared to control C57Bl/6 mice. mRNA expression of the anti-inflammatory cytokines IL-4、IL-10, TGF-Βin Tregs were decreased in KK-Ay mice, ob/ob mice and db/db mice compared to control C57Bl/6 mice. Large numbers of CD8+effector T cells and inflammatory macrophage(M1) infiltrated liver tissue in ob/ob mice and db/db mice. Our findings suggest that the reduced anti-inflammatory effect of Tregs develop steatohepatitis.
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