2011 Fiscal Year Final Research Report
Establishment of hepatic stellate cell de-activation in liver fibrosis model using 3 dimensional bio artificial liver
| Project/Area Number |
22790673
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 病態モデル / 人工臓器工学 / 肝線維化 / 肝星細胞 |
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| Research Abstract |
Bio artificial liver model which is co-cultured with immortal mouse stellate cell, endothelial cell and hepatocyte using radial flow bioreactor showed activity of liver fibrosis in conventional culture fluid(2% FBS+ASF-104N). When an anti-fibrotic agent was added in this bio artificial liver model, LRAT which reflect ability to store vitamin A into stellate cell was re-expressed in mRNA and protein level.
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[Journal Article] Transplantation of liver organoids in the omentum and kidney2011
Author(s)
Saito R, Ishii Y, Ito R, Nagatsuma K, Tanaka K, Saito M, Maehashi H, Nomoto H, Ohkawa K, Mano M, Aizawa M, Hano H, Yanaga K, Matsuura T.
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Journal Title
Artif Organs
Volume: 35
Pages: 80-3
DOI
Peer Reviewed
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