2012 Fiscal Year Final Research Report
Development of the biomarker in urine of cardiovascular and kidney disease.
| Project/Area Number |
22790715
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床心血管病態学 / バイオマーカー / 生理活性ペプチド |
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| Research Abstract |
I isolated and identified a new angiotensinogen-derived peptide from the human urine. Then, I made antiserum to use rabbits for this peptide. And I established assay system. So, I collected urine samples and measured of this peptide by radioimmunoassay. I found that urinary new peptide/creatinin ratio was significantly higher than the estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 group in other two groups (eGFR >90, 90-30 ml/min/1.73 m2). And, when compared with the protein urea plas in diabetes, the urinary new peptide/creatinin ratio was significantly higher than in protein urea minus group. In addition, urinary this peptide is associated renal derangement in patients with diabetic nephropathy. In addition, this peptide is abundant in a wide range of organs and tissues including the heart and kidney of human by immunohistochemistory.
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[Journal Article] Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension2013
Author(s)
Moniwa N, Varagic J, Ahmad S, VanCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, SequeiraLopez ML, Ferrario CM
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Journal Title
Hypertension
Volume: 61(2)
Pages: 417-424
Peer Reviewed
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[Presentation] Effect of adrenomedullin administration in two rat models of experimental inflammatory colitis2010
Author(s)
Nagata S, Hikosaka T, Ashizuka S, Tsuruda T, Kuwasako K, Kato J, Kitamura K
Organizer
7th International Symposia on the CGRP Family; CGRP, Adrenomedullin, Amylin, Intermedin and Calcitonin
Place of Presentation
Queenstown, New Zealand
Year and Date
20100800
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[Remarks] 研究会 (1)永田さやか、北村和雄:循環器・腎臓疾患の新しいバイオマーカーの開発を目指して.第2回 ペプチド・ホルモン若手研究会、2012 年 3 月、広島
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[Remarks] (2)永田さやか、加藤丈司、朝見麻希、北村和雄:ラット血中・組織中のアンジオテンシン II(Ang II)産生におけるプロアンジオテンシン-12(proang-12)の役割.第2回 Molecular Cardiovascular Conference、2011 年 9 月、北海道
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[Remarks] (3)Hikosaka T, Nagata S, Ashizuka S, Inatsu H, Kitamura K: Therapeutic effect of adrenomedullin administration in two rat models of experimental inflammatory colitis. 第2回 Molecular Cardiovascular Conference、2011 年 9 月、北海道
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[Remarks] (4)永田さやか、加藤丈司、桑迫健二、北村和雄:低塩刺激および RA 系阻害薬投与に伴うプロアンジオテンシン-12(proang-12)やレニン・アンジオテンシン系(RA 系)因子の血中・組織中の変化.第15回アンジオテンシンカンファレンス、2010 年 2 月、大阪
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