2012 Fiscal Year Final Research Report
Individualized treatment of lung cancer based on the resistant mutation in EGFR gene from circulating tumor cells
| Project/Area Number |
22790746
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
INOUE Akira 東北大学, 病院, 特任准教授 (70361087)
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| Project Period (FY) |
2010 – 2012
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| Keywords | EGFR / 個別化治療 / 循環腫瘍細胞 |
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| Research Abstract |
Prospective study of individualized treatment for lung cancer resistant to epidermal growth factor receptor tyrosine kinase based on the T790M resistant mutation status detected from DNA of circulating tumor cells (CTC) was conducted. At the point when 6 enrolled patients were analyzed, it was revealed that the positive rate of CTC was quite lower than expected and that obtained DNA of CTC was too small to detect the T790M mutation. Thus the study was terminated halfway.
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