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2012 Fiscal Year Final Research Report

Individualized treatment of lung cancer based on the resistant mutation in EGFR gene from circulating tumor cells

Research Project

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Project/Area Number 22790746
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

INOUE Akira  東北大学, 病院, 特任准教授 (70361087)

Project Period (FY) 2010 – 2012
KeywordsEGFR / 個別化治療 / 循環腫瘍細胞
Research Abstract

Prospective study of individualized treatment for lung cancer resistant to epidermal growth factor receptor tyrosine kinase based on the T790M resistant mutation status detected from DNA of circulating tumor cells (CTC) was conducted. At the point when 6 enrolled patients were analyzed, it was revealed that the positive rate of CTC was quite lower than expected and that obtained DNA of CTC was too small to detect the T790M mutation. Thus the study was terminated halfway.

  • Research Products

    (28 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (17 results)

  • [Journal Article] LUX-Lung 4: A Phase II Trial of Afatinib in Patients withAdvanced, Non-Small Cell Lung Cancer who progressed on Prior Treatment with Erlotinib, Gefitinib, or Both2013

    • Author(s)
      Katakami N, Atagi S, Inoue A, et al
    • Journal Title

      J Clin Oncol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Impact of epidermal growth factor receptor inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis2013

    • Author(s)
      Lee CK, Brown C, Inoue A, et al
    • Journal Title

      J Natl Cancer I

      Volume: 105 Pages: 595-605

    • DOI

      doi:10.1093/jnci/djt072.

    • Peer Reviewed
  • [Journal Article] Interstitial Lung Disease associated with Gefitinib in Japanese Patients with EGFR MutatedNon-Small Cell Lung Cancer: Combined analysis of two phase III trials (NEJ 002 and WJTOG 3405)2013

    • Author(s)
      Akamatsu H, Inoue A, Mitsudomi T, et al
    • Journal Title

      Jpn Clin Oncol

      Volume: 43 Pages: 664-8

    • DOI

      doi:10.1093/jjco/hyt049.

    • Peer Reviewed
  • [Journal Article] Updated Overall Survival Results from A Randomized Phase III Trial Comparing Gefitinib with Carboplatin-Paclitaxel for Chemo-Naive Non-Small Cell Lung Cancer with Sensitive EGFR Gene Mutations (NEJ002)2013

    • Author(s)
      Inoue A, Kobayashi K, Maemondo M, et al
    • Journal Title

      Ann Oncol

      Volume: 24 Pages: 54-9

    • DOI

      doi:10.1093/annonc/mds214.

    • Peer Reviewed
  • [Journal Article] Quality of Life with Gefitinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer: Quality of Life Analysis of North East Japan Study Group 002 Trial2012

    • Author(s)
      Oizumi S, Kobayashi K, Inoue A, et al
    • Journal Title

      Oncologist

      Volume: 17 Pages: 863-70

    • DOI

      doi:10.1634/theoncologist.2011-0426.

    • Peer Reviewed
  • [Journal Article] First-Line Gefitinib in Patients Aged 75 or Older With Advanced Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Mutations: NEJ 003 Study2012

    • Author(s)
      Maemondo M, Minegishi Y, Inoue A, et al
    • Journal Title

      J Thorac Oncol

      Volume: 7 Pages: 1417-22

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22895139

    • Peer Reviewed
  • [Journal Article] A prospective PCR-based screening for the EML4-ALK oncogene innon-small cell lung cancer2012

    • Author(s)
      Soda M, Isobe K, Inoue A, et al
    • Journal Title

      Clin Cancer Res

      Volume: 18 Pages: 5682-9

    • DOI

      doi:10.1158/1078-0432.CCR-11-2947.

    • Peer Reviewed
  • [Journal Article] Miliary brainmetastases in 2cases with advanced non-small cell lung cancer harboring EGFR mutation during gefitinib treatment2012

    • Author(s)
      Mochizuki S, Nishimura N, Inoue A, et al
    • Journal Title

      Respiratory Investigation

      Volume: 50 Pages: 117-21

    • DOI

      doi:10.1016/j.resinv.2012.06.002.

    • Peer Reviewed
  • [Journal Article] Carcinoembryonicantigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma2012

    • Author(s)
      Kobayashi M, Miki Y, Inoue A, et al
    • Journal Title

      Brit J Cancer

      Volume: 107 Pages: 1745-53

    • DOI

      doi:10.1038/bjc.2012.422.

    • Peer Reviewed
  • [Journal Article] Low-dose Gefitinib Treatment for Patients with Advanced Non-small Cell Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations2011

    • Author(s)
      Satoh H, Inoue A, Kobayashi K, et al
    • Journal Title

      J Thorac Oncol

      Volume: 6 Pages: 1413-7

    • DOI

      doi:10.1097/JTO.0b013e31821d43a8.

    • Peer Reviewed
  • [Journal Article] Optimization of Dosing for EGFR-Mutant Non-Small Cell LungCancer with Evolutionary CancerModeling2011

    • Author(s)
      Chmielecki J, Foo J, Inoue A, et al
    • Journal Title

      Sci Transl Med

      Volume: 3 Pages: 90ra59

    • DOI

      doi:10.1126/scitranslmed.3002356.

    • Peer Reviewed
  • [Presentation] クリゾチニブによる薬剤性肺障害を発症した後、同剤を再投与した一例2013

    • Author(s)
      井上彰、ほか
    • Organizer
      第96回日本呼吸器学会東北地方会
    • Place of Presentation
      秋田
    • Year and Date
      2013-03-23
  • [Presentation] 肺癌治療に関連する臨床的な知見2013

    • Author(s)
      井上彰
    • Organizer
      第32回日本画像医学会教育講演15
    • Place of Presentation
      東京
    • Year and Date
      2013-02-23
  • [Presentation] 進行肺がんの薬物療法2012

    • Author(s)
      井上彰
    • Organizer
      第7回医療の質・安全学会学術集会シンポジウム10
    • Place of Presentation
      大宮
    • Year and Date
      2012-11-24
  • [Presentation] EGFR-TKIが教えてくれたこと2012

    • Author(s)
      井上彰
    • Organizer
      第53回日本肺癌学会総会シンポジウム1
    • Place of Presentation
      岡山
    • Year and Date
      2012-11-08
  • [Presentation] Randomized phase II trial comparing carboplatin with weekly paclitaxel and docetaxel alone for elderly patients with non-small cell lung cancer:NJLCG08032012

    • Author(s)
      井上彰 、ほか
    • Organizer
      第10回日本臨床腫瘍学会International session7
    • Place of Presentation
      大阪
    • Year and Date
      2012-07-28
  • [Presentation] クリゾチニブによる急性肺障害の一例2012

    • Author(s)
      井上彰、ほか
    • Organizer
      第51回日本肺癌学会東北支部会
    • Place of Presentation
      弘前
    • Year and Date
      2012-07-21
  • [Presentation] 臨床論文の書き方2012

    • Author(s)
      井上彰
    • Organizer
      第7回日本緩和医療薬学会教育セミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-06-29
  • [Presentation] EGFR2012

    • Author(s)
      井上彰
    • Organizer
      第38回肺癌診断会シンポジウム2
    • Place of Presentation
      越後湯沢
    • Year and Date
      2012-06-23
  • [Presentation] 分子標的治療2012

    • Author(s)
      井上彰
    • Organizer
      第29回日本呼吸器外科学会総会教育講演
    • Place of Presentation
      秋田
    • Year and Date
      2012-05-17
  • [Presentation] Molecular mechanisms of resistance to EGFR-TKI2011

    • Author(s)
      Inoue A
    • Organizer
      16^<th> Congress of APSR (Symposium 18)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-11-06
  • [Presentation] Evidences ofEGFR-targeted therapy for NSCLC in Asia2011

    • Author(s)
      Inoue A
    • Organizer
      16^<th> Congress of APSR (Symposium 16)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-11-06
  • [Presentation] 肺癌の分子標的治療の進歩(EGFR-TKI)2011

    • Author(s)
      井上彰
    • Organizer
      第52回日本肺癌学会シンポジウム1
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-03
  • [Presentation] Mutation-based clinical trials of EGFR-TKI in Japan2011

    • Author(s)
      井上彰
    • Organizer
      第9回日本臨床腫瘍学会 International session3
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-23
  • [Presentation] 肺癌の臨床における抗EGFR療法の展開2011

    • Author(s)
      井上彰
    • Organizer
      第9回日本臨床腫瘍学会シンポジウム03
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-22
  • [Presentation] Final overall survival results of NEJ002, a phase III trial comparing gefitinib to carboplatin (CBDCA)plus paclitaxel (TXL) as the first-line treatment for advanced non-smallcell lung cancer (NSCLC) with EGFR mutations2011

    • Author(s)
      Inoue A, Kobayashi K, Maemondo M, et al
    • Organizer
      ASCO annual meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-06-06
  • [Presentation] What we can do afterpresent TKI failure- Acquired resistance?2010

    • Author(s)
      Inoue A
    • Organizer
      TSPCCM annual meeting
    • Place of Presentation
      Taipei, Taipei
    • Year and Date
      2010-12-11
  • [Presentation] Recent topics about theindividualized treatment for advanced non-small cell lung cancer2010

    • Author(s)
      Inoue A
    • Organizer
      KASLC annual meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-19

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Published: 2014-08-29  

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