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2011 Fiscal Year Final Research Report

Roles of IL-25 in the development of pulmonary arterial inflammation and remodeling

Research Project

  • PDF
Project/Area Number 22790748
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

IKEDA Kei  千葉大学, 医学部・附属病院, 助教 (10456014)

Project Period (FY) 2010 – 2011
KeywordsIL-25 / 肺血管リモデリング
Research Abstract

We generated lung specific IL-25 transgenic (C57BL/6 CC10 IL-25) mice and C57BL/6 CC10 IL-25 NKT cell-deficient mice, and performed histopathological analysis, immune-histochemistry, and gene expression analysis. The results suggest that IL-25-NKT cell pathway is involved in the development of pulmonary arterial muscularization.

  • Research Products

    (29 results)

All 2011 2010 Other

All Journal Article (8 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Int Immunol. Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice2011

    • Author(s)
      Oya Y, Watanabe N, Ikeda K, et al
    • Journal Title

      Int Immunol

      Volume: 23 Pages: 335-344

  • [Journal Article] A patient with neuromyelitis optica with positive anti-Ro (SS-A) antibody presenting with intractable hiccup and nausea2011

    • Author(s)
      Koga S, Ikeda K, Nakagomi D, et al
    • Journal Title

      Mod Rheumatol

      Volume: 21 Pages: 561-562

  • [Journal Article] Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis2010

    • Author(s)
      Horikoshi M, Suzuki T, Ikeda K, et al
    • Journal Title

      Mod Rheumatol

      Volume: 20 Pages: 556-560

  • [Journal Article] B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses2010

    • Author(s)
      Kashiwakuma D, Suto A, Ikeda K, et al
    • Journal Title

      J Immunol

      Volume: 185 Pages: 2730-2736

  • [Journal Article] Role of Th2 cells in IgG4-related lacrimal gland enlargement2010

    • Author(s)
      Kanari H, Kagami S, Ikeda K, et al
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 s1 Pages: 47-53

  • [Journal Article] c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells2010

    • Author(s)
      Hiramatsu Y, Suto A, Ikeda K, et al
    • Journal Title

      J Leukoc Biol

      Volume: 87 Pages: 703-712

  • [Journal Article] Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis : two case reports and a review of 36 reported cases

    • Author(s)
      Nakagomi D, Ikeda K, et al
    • Journal Title

      Rheumatol Int in press

  • [Journal Article] A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis

    • Author(s)
      Oki M, Watanabe N, Ikeda K, et al
    • Journal Title

      Clin Dev Immunol, in press

  • [Presentation] New approach through a beneficial tool-The application of ultrasonographic evaluation of synovium in the management of rheumatoid arthritis2011

    • Author(s)
      K. Ikeda
    • Organizer
      The 5^<th> Asian Congress on Autoimmunity
    • Place of Presentation
      Satellite Symposium. Singapore
    • Year and Date
      2011-11-18
  • [Presentation] IgG4関連涙腺腫脹症例におけるPGD2-CRTH2経路の役割の解析2011

    • Author(s)
      加々美新一郎, 細川淳一, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Year and Date
      2011-11-10
  • [Presentation] The impact of ultrasonography on the classification of rheumatoid arthritis with 2010 ACR/EULAR criteria : ultrasound-combined classification with two different definitions of gray-scale synovitis for joint involvement2011

    • Author(s)
      Nakagomi, K. Ikeda, A. Okubo, et al
    • Organizer
      ACR (American College of Rheumatology) Annual Scientific Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-06
  • [Presentation] リウマチ性疾患の画像滑膜ドプラ血流測定に対するPRF(Pulse Repetition Frequency)の与える影響の検討2011

    • Author(s)
      池田啓, 瀬戸洋平, 大野滋, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-20
  • [Presentation] 生物学的製剤増量、変更関節リウマチ患者はどう評価しているか?2011

    • Author(s)
      松村竜太郎, 池田啓, 海辺剛志, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-19
  • [Presentation] トシリズマブ関節リウマチ患者の骨代謝に対するトシリズマブの効果2011

    • Author(s)
      松浦功, 山形美絵子, 池田啓, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-19
  • [Presentation] 全身性エリテマトーデスの治療中に腸管嚢腫様気腫症および気腫性膀胱炎を合併した一例2011

    • Author(s)
      大久保綾子, 岩本太郎, 池田啓, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-19
  • [Presentation] トシリズマブDNAアレイ解析によるトシリズマブの関節リウマチに対する薬効予測2011

    • Author(s)
      古田俊介, 山形美絵子, 池田啓, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-18
  • [Presentation] リウマチ性疾患の画像滑膜ドプラ血流測定に対する検者、機器、ならびにプローブの劣化の与える影響の検討2011

    • Author(s)
      池田啓, 瀬戸洋平, 大野滋, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-07-18
  • [Presentation] The impact of ultrasonography on the classification of RA with 2010 ACR/EULAR criteria2011

    • Author(s)
      D. Nakagomi, K. Ikeda, A. Okubo, et al
    • Organizer
      EULAR(European League Against Rheumatism)
    • Place of Presentation
      Congress, London, UK
    • Year and Date
      2011-05-27
  • [Presentation] 気管支喘息患者のQOL調査2011

    • Author(s)
      横田雅也, 須藤明, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会春季臨床大会
    • Year and Date
      2011-05-15
  • [Presentation] Nutcracker esophagus(NE)を合併した好酸球性食道炎の一例2011

    • Author(s)
      大久保綾子, 中込大樹, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Year and Date
      2011-05-15
  • [Presentation] 膠原病ならびにリウマチ性疾患患者のQuality of Life調査2011

    • Author(s)
      池田啓, 川島広稔, 高橋健太郎, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Year and Date
      2011-05-15
  • [Presentation] 肺動脈リモデリングにおけるIL-25の働き2010

    • Author(s)
      丹羽佑輔, 川島沙紀, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Year and Date
      2010-11-27
  • [Presentation] 両側視神経炎を合併したChurg-Strauss症候群の一例2010

    • Author(s)
      中込大樹, 古賀俊輔, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Year and Date
      2010-11-26
  • [Presentation] 両側視神経炎を合併したChurg-Strauss症候群の1例2010

    • Author(s)
      中込大樹, 古賀俊輔, 池田啓, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Year and Date
      2010-11-26
  • [Presentation] 高用量ステロイド投与中の膠原病患者へのST合剤投与による副作用発現率と危険因子に関する研究2010

    • Author(s)
      林彰子, 増田和司, 池田啓, 他
    • Organizer
      第20回日本医療薬学会年会
    • Year and Date
      2010-11-13
  • [Presentation] The application and benefit of ultrasonography in rheumatic conditions2010

    • Author(s)
      K. Ikeda
    • Organizer
      TLAR (Turkish League Against Rheumatism) Symposium in Antalya : The Benefit of Ultrasonography and Nuclear Medicine in Rheumatic Conditions
    • Place of Presentation
      Antalya, Turkey
    • Year and Date
      2010-10-23
  • [Presentation] How to evaluate synovial inflammation in each joint with ultrasound in rheumatic conditions2010

    • Author(s)
      K. Ikeda
    • Organizer
      TLAR (Turkish League Against Rheumatism) Symposium in Antalya : The Benefit of Ultrasonography and Nuclear Medicine in Rheumatic Conditions
    • Place of Presentation
      Antalya, Turkey
    • Year and Date
      2010-10-23
  • [Presentation] Comparison of ultrasonographic findings with established measures in the evaluation of drug response in rheumatoid arthritis2010

    • Author(s)
      K. Ikeda, D. Nakagomi, H. Kawashima, et al
    • Organizer
      EULAR (European League Against Rheumatism)
    • Place of Presentation
      Congress 2010, Roma, Italy
    • Year and Date
      2010-06-18
  • [Remarks]

    • URL

      http://www.m.chiba-u.jp/class/allergy/index.html

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Published: 2013-07-31  

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