2011 Fiscal Year Final Research Report
Roles of IL-25 in the development of pulmonary arterial inflammation and remodeling
| Project/Area Number |
22790748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
IKEDA Kei 千葉大学, 医学部・附属病院, 助教 (10456014)
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| Project Period (FY) |
2010 – 2011
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| Keywords | IL-25 / 肺血管リモデリング |
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| Research Abstract |
We generated lung specific IL-25 transgenic (C57BL/6 CC10 IL-25) mice and C57BL/6 CC10 IL-25 NKT cell-deficient mice, and performed histopathological analysis, immune-histochemistry, and gene expression analysis. The results suggest that IL-25-NKT cell pathway is involved in the development of pulmonary arterial muscularization.
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