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2012 Fiscal Year Final Research Report

Development of the new therapy for renal tubule regeneration by the acute kidney injury by regenerative medicine

Research Project

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Project/Area Number 22790793
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKochi University

Principal Investigator

OGATA Koji  高知大学, 医学部附属病院, 特任助教 (30527586)

Project Period (FY) 2010 – 2012
Keywords再生医療 / 尿中バイオマーカー / 尿細管細胞
Research Abstract

A possibility that HNF-1beta which is a transcription factor revealed to a kidney or liver was participating in the renal tubular cell reproduction at the time of the acute kidney injury after ischemia re-perfusion was able to be considered.Therefore, we did various researches which used the proximal tubular cell, and reported the result to American Journal of Physiology(303:F689-F699,2012) as a thesis, and announced also at the international society.

  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (4 results) Presentation (8 results) Book (6 results)

  • [Journal Article] Upregulation ofHNF-1β during experimental acutekidney injury plays a crucial role inrenal tubule regeneration2012

    • Author(s)
      Ogata K, ShimamuraY, HamadaK, HisaM, BunM, OkadaN, InoueK, TaniguchiY, Ishihara M, Kagawa T, Horino T,FujimotoS, Terada Y
    • Journal Title

      AmericanJournal of Physiology

      Volume: 303 Pages: F689-F699

  • [Journal Article] Aldosterone Stimulates NF-kB Activityand Transcription of ICAM-1 and CTGFin Rat Mesangial Cells via SGK(Serum and Glucocorticoid-inducible Protein Kinase)-12012

    • Author(s)
      Terada Y, Ueda S, Hamada K, ShimamuraY, Ogata K, Inoue K, Taniguchi Y,Kagawa T, Horino T, Takao T
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 16 Pages: 81-88

  • [Journal Article] Possible involvement ofintracellular angiotensin IIreceptor in high-glucose-induceddamage in renal proximal tubular cells2011

    • Author(s)
      Takao T, Horino T, Kagawa T, MatsumotoR, Shimamura Y, Ogata K, Inoue K,Taniguchi Y, Taguchi T, Morita T,Terada Y
    • Journal Title

      Journal of Nephrology

      Volume: 24(03) Pages: 218-224

  • [Journal Article] Cisplatin-induced macroautophagyoccurs prior to apoptosis in proximaltubules in vivo2010

    • Author(s)
      Inoue K,Kuwana H,Shimamura Y,OgataK,Taniguchi Y,Kagawa T,Horino T,Morita T, Mizushima N,Terada Y
    • Journal Title

      Clinical andexperimental Nephrology

      Volume: 14 Pages: 112-122

  • [Presentation] たこつぼ型心筋症を合併した強皮症腎クリーゼの一例2012

    • Author(s)
      緒方巧二,江間宏樹,島村芳子,井上紘輔,高田浩史,次田誠,香川 亨,寺田典生
    • Organizer
      第42回日本腎臓学会西部学術大会
    • Place of Presentation
      宜野湾
    • Year and Date
      20121026-27
  • [Presentation] BNIP3は急性腎障害において誘導され近位尿細管細胞のAutophagyとMitophagyを調整する2012

    • Author(s)
      緒方巧二,石原正行,久雅之,文勝徹,島村芳子,濱田佳寿,平野世紀,井上紘輔,香川 亨,寺田典生
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20120601-03
  • [Presentation] ActivatedProrenin and (Pro)renin Receptor AreUp-Regukated in Glomeruli of DiabeticNephropathy and IgA Nephropathy UsingRenal Biopsy Specimen2011

    • Author(s)
      Ogata K, Shimamura Y, Inoue K, KagawaT, Nishiyama A, Terada Y
    • Organizer
      ASN(AmericanSociety of Nephrology) Kidney week
    • Place of Presentation
      PhiladelphiaUSA.
    • Year and Date
      20111108-13
  • [Presentation] HNF-1β,SOCS3,STAT3の情報伝達系は急性腎障害での尿細管再生と形成に重要な役割を果たす2011

    • Author(s)
      緒方巧二,濱田佳寿,江間宏樹,島村芳子,井上紘輔,谷口義典,香川 亨,寺田典生
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20110615-17
  • [Presentation] Up-Regulated HNF-1 β duringExperimental Acute Kidney Injury Plays a Crucial Role in Renal Tubular Regeneration.2010

    • Author(s)
      Ogata K, Ueda S, Shimamura Y, Inoue K,Taniguchi Y, Ishihara M, Kagawa T,Horino T, Takao T, Terada Y
    • Organizer
      American Society of Nephrology 43th Annual Meeting and Scientific Exposition.
    • Place of Presentation
      Denver in USA
    • Year and Date
      20101116-21
  • [Presentation] 急性腎障害での尿細管再生・増殖におけるHNF-1β,SOCS3,STAT3系の役割2010

    • Author(s)
      緒方巧二,島村芳子,井上紘輔,谷口義典,香川 亨,堀野太郎,高尾俊弘,森田達仁,寺田典生
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      20100616-18
  • [Presentation] MPO-ANCA関連血管炎による肥厚生硬膜炎の一例2010

    • Author(s)
      緒方巧二,堀野太郎,田口崇文,島村芳子,谷口義典,井上紘輔,香川 亨,森田達仁,寺田典生
    • Organizer
      第54回日本リウマチ学会総会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20100422-25
  • [Presentation] HNF-1β,SOCS3,and STAT3 are regulatedduring experimental acute kidneyinjury in vivo and affect renaltubular proliferation in vitro2010

    • Author(s)
      Ogata K, Shimamura Y, Inoue K,Taniguchi Y, Kagawa T, Horino T, TakaoT, Morita T, Terada Y
    • Organizer
      ISNNEXUS Symposium.
    • Place of Presentation
      Kyoto
    • Year and Date
      20100415-18
  • [Book] AKIの病態,管理と予後.医薬ジャーナル11月号48(11)2012

    • Author(s)
      緒方巧二,松本竜季,濱田佳寿,谷口義典,寺田典生
    • Total Pages
      164-166
  • [Book] 管内増殖性糸球体腎炎.別冊 腎臓症候群2012

    • Author(s)
      緒方巧二,島村芳子,井上紘輔,香川 亨,寺田典生
    • Total Pages
      60-61
    • Publisher
      日本臨牀社
  • [Book] AKIの予後と再生療法.AKI急性腎障害のすべて 基礎から臨床までの最新知見,PartI臨床総論2012

    • Author(s)
      緒方巧二,寺田典生
    • Total Pages
      86-92
    • Publisher
      南江堂
  • [Book] 巣状糸球体硬化症 -病因から治療まで-.臨牀と研究 第88巻第4号2011

    • Author(s)
      緒方巧二,濱田佳寿,上田訓子,島村芳子,井上紘輔,谷口義典,香川 亨,寺田典生
    • Total Pages
      491-496
  • [Book] 炭酸脱水酵素阻害薬、浸透圧利尿薬、バソプレッシン拮抗薬(臨床医が知っておくべきこと、将来性を含めて)2011

    • Author(s)
      緒方巧二,島村芳子,井上紘輔,香川 亨,寺田典生
    • Total Pages
      731-733
    • Publisher
      Modern Physician
  • [Book] 多発性骨髄腫と腎障害.綜合臨牀vol.60(6)2011

    • Author(s)
      緒方巧二,上田訓子,島村芳子,井上紘輔,香川 亨,寺田典生
    • Total Pages
      1421-1424

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Published: 2014-08-29  

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