2012 Fiscal Year Final Research Report
Development of the new therapy for renal tubule regeneration by the acute kidney injury by regenerative medicine
| Project/Area Number |
22790793
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
OGATA Koji 高知大学, 医学部附属病院, 特任助教 (30527586)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 再生医療 / 尿中バイオマーカー / 尿細管細胞 |
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| Research Abstract |
A possibility that HNF-1beta which is a transcription factor revealed to a kidney or liver was participating in the renal tubular cell reproduction at the time of the acute kidney injury after ischemia re-perfusion was able to be considered.Therefore, we did various researches which used the proximal tubular cell, and reported the result to American Journal of Physiology(303:F689-F699,2012) as a thesis, and announced also at the international society.
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[Journal Article] Upregulation ofHNF-1β during experimental acutekidney injury plays a crucial role inrenal tubule regeneration2012
Author(s)
Ogata K, ShimamuraY, HamadaK, HisaM, BunM, OkadaN, InoueK, TaniguchiY, Ishihara M, Kagawa T, Horino T,FujimotoS, Terada Y
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Journal Title
AmericanJournal of Physiology
Volume: 303
Pages: F689-F699
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[Journal Article] Possible involvement ofintracellular angiotensin IIreceptor in high-glucose-induceddamage in renal proximal tubular cells2011
Author(s)
Takao T, Horino T, Kagawa T, MatsumotoR, Shimamura Y, Ogata K, Inoue K,Taniguchi Y, Taguchi T, Morita T,Terada Y
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Journal Title
Journal of Nephrology
Volume: 24(03)
Pages: 218-224
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[Presentation] 急性腎障害での尿細管再生・増殖におけるHNF-1β,SOCS3,STAT3系の役割2010
Author(s)
緒方巧二,島村芳子,井上紘輔,谷口義典,香川 亨,堀野太郎,高尾俊弘,森田達仁,寺田典生
Organizer
第53回日本腎臓学会学術総会
Place of Presentation
神戸
Year and Date
20100616-18
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[Presentation] HNF-1β,SOCS3,and STAT3 are regulatedduring experimental acute kidneyinjury in vivo and affect renaltubular proliferation in vitro2010
Author(s)
Ogata K, Shimamura Y, Inoue K,Taniguchi Y, Kagawa T, Horino T, TakaoT, Morita T, Terada Y
Organizer
ISNNEXUS Symposium.
Place of Presentation
Kyoto
Year and Date
20100415-18
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