2011 Fiscal Year Final Research Report
Studies on action mechanism of protective effects of angiogenesis inhibitor against the diabetic nephropathy.
| Project/Area Number |
22790797
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腎臓学 / 糖尿病性腎症 / 糖尿病 / 腎疾患 / 血管新生抑制因子 |
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| Research Abstract |
The pathological conditions of diabetes originate in a systemic microangiopathy. In this study, we investigated the mechanisms of action by which angiogenesis inhibitor angiostatin protects the diabetic nephropathy. Angiostatin attenuated the endothelial dysfunction through the inhibition of nuclear translocation of NF-κB induced by inflammatory cytokine. We showed the binding between angiostatin and its novel target receptor. It is expected that these observations contribute to the therapeutic effects of angiostatin to the diabetic nephropathy.
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