2012 Fiscal Year Final Research Report
Analysis of the effect of human living specimen on amyloid β-protein oligomerization
| Project/Area Number |
22790815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kanazawa University |
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Principal Investigator |
ONO Kenjiro 金沢大学, 大学病院, 講師 (70377381)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳神経疾患 / 認知症 / アミロイドβ蛋白 / オリゴマー |
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| Research Abstract |
Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ40 and Aβ42 usingphoto-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ40 and Aβ42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization.
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Research Products
(51 results)
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[Journal Article] Phenolic compounds prevent amyloid β-Protein oligomerization and synaptic dysfunction by site specific binding2012
Author(s)
Ono K, Li L, Takamura Y, Yoshiie Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 14631-14643
DOI
Peer Reviewed
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[Journal Article] Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G2012
Author(s)
Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G
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Journal Title
J. Neurosci
Volume: 11
Pages: 5144-5150
DOI
Peer Reviewed
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[Journal Article] Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease2012
Author(s)
Shima K, Samuraki M, Chen WP, Yanase D, Noguchi-Shinohara M, Takeda N, Ono K, Yoshita M, Miyazaki Y, Matsuda H, Yamada M, Matsunari I
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Journal Title
Neurobiol. Aging
Volume: 33
Pages: 2006-2017
DOI
Peer Reviewed
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[Journal Article] Effect of Age and Sex mismatched Normal Database on Diagnostic Performance of 18F-FDG PET for Alzheimer's Disease: The Ishikawa Brain Imaging Study2011
Author(s)
Chen WP, Samuraki M, Shima K, Yanase D, Nozomi, Takeda N, Miyazaki Y, Ono K, Yoshita M, Nishimura S, Yamada M, Matsunari I
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Journal Title
Nucl. Med. Commun
Volume: 32
Pages: 1128-1133
DOI
Peer Reviewed
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[Journal Article] Carvedilol as a potential novel agent for the treatment of Alzheimer's disease2011
Author(s)
Wang J, Ono K, Dickstein D, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Ferruzzi MG, Pavlides C, Ho L, Hof P, Teplow DB, Pasinetti GM
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Journal Title
Neurobiol. Aging
Volume: 32
Pages: e1-e12
DOI
Peer Reviewed
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[Journal Article] A comparison of the diagnosticsensitivity of MRI, CBF-SPECT, FDG-PET, and cerebrospinal fluid biomarkers for detecting Alzheimer's disease in a memory clinic2010
Author(s)
Morinaga A, Ono K, Ikeda T, Ikeda Y, Shima K, Shinohara M,Samuraki M,Yanase D, Yoshita M, Mastunari I, Yamada M
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Journal Title
Dement. Geriatr. Cogn. Disord
Volume: 30
Pages: 285-292
DOI
Peer Reviewed
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