2011 Fiscal Year Final Research Report
Parkin dysfunction results in defective depolarization-induced exocytosis
| Project/Area Number |
22790832
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | パーキン / 細胞骨格蛋白 / 放出機構 / 糖尿病 |
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| Research Abstract |
We reported that Parkin-deficient mice have shown impaired inuslin exocytosis and neurotransmission by altered expression of proteins that are involved in the regulation of cytoskeleton polymerization. Interaction of cytoskeleton protein and syntaxin1 was increased in parkin-deficent mice brain. Parkin-deficent mice had impaired insulin exocytosis in OGTT. Parkin may play a role in cytoskeleton polymerization and neurotransmition and insulin exocytosis. Parkin may be associated with an increased risk of diabetes onset.
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[Journal Article]2011
Author(s)
Hattori N, Eguchi H, Imaizumi M, Saiki S, Sato S, Nagamatsu S
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Journal Title
Rinsho Shinkeigaku
Volume: 51(11)
Pages: 986-7
Peer Reviewed
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[Journal Article]2011
Author(s)
Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
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Journal Title
Neurobiol Dis
Volume: 43(3)
Pages: 651-62
Peer Reviewed
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[Journal Article]2010
Author(s)
Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N
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Journal Title
FEBS Lett
Volume: 584(6)
Pages: 1073-9
Peer Reviewed
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