2011 Fiscal Year Final Research Report
Analysis of the Anti-Atherosclerosis Mechanism of Pioglitazone
| Project/Area Number |
22790878
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
INOUE Mariko 独立行政法人国立健康・栄養研究所, 臨床栄養研究部メタボリックシンドローム研究室 (80511477)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アディポネクチン / 動脈硬化 / チアゾリジン誘導体 |
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| Research Abstract |
We assessed cuff-induced neointimal formation of the artery in both wild type and adiponectin knockout mice following pioglitazone treatment. Though significant improvement of neointimal formation was observed only in wild type mice after 3 weeks of pioglitazone treatment, it was observed in both wild type mice and adiponectin knockout mice after 8 weeks. Inflammation in neointimal formation region and proliferation of vascular smooth muscle cells were suppressed by 8 weeks treatment in adiponectin knockout mice. Thus, it is indicated that pioglitazone ameliorates neointimal formation via adiponectin-dependent pathway and adiponectin-independent pathway.
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[Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle2011
Author(s)
Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
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Journal Title
Cell Metabolism
Volume: 13巻
Pages: 294-307
Peer Reviewed
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