2011 Fiscal Year Final Research Report
The study of feeding and metabolism regulated by nesfatin-1-oxytocin-POMC system
| Project/Area Number |
22790887
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
MAEJIMA Yuko 自治医科大学, 医学部, 助教 (40438669)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 内分泌学 / オキシトシン / 弓状核 / プロオピオメラノコルチン |
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| Research Abstract |
The activation of proopiomelanocortin neurons in Nucleus tractus solitarius(NTS) by oxytocin has been reported. However, the effect of oxytocin on POMC neurons in arcuate nucleus(ARC) has not been examined yet. This study clarified that oxytocin is physiological anorectic peptides, and activates ARC POMC neurons, as well as NTS POMC neurons. It is also suggested that oxytocin could activated ARC POMC neurons even in the leptin resistant animal model.
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