2011 Fiscal Year Final Research Report
Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor
| Project/Area Number |
22790892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORI Kenji 独立行政法人国立循環器病研究センター, 生化学部, 室長 (00416223)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 内分泌 / 神経ペプチド / 生理活性ペプチド / 受容体 |
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| Research Abstract |
A novel bioactive peptide was identified by in silico screening. This peptide was produced from a precursor protein of known neuropeptide by differential proteolytic processing. Intracerebroventricular administration of peptide to rats induced increase in plasma concentration of specific pituitary hormone. A specific binding of radiolabeled peptide to a section of rat brain was observed. To elucidate the physiological role of a newly identified peptide, mice lacking only this peptide were generated.
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[Journal Article] Identification of the novel neuropeptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011
Author(s)
Ida T, Takahashi, T, Tominaga H, Sato T, Kume K, Ozaki M, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Pages: 872-877
DOI
Peer Reviewed
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