2011 Fiscal Year Final Research Report
Clarification of pathophysiological role of monomer adiponectin
| Project/Area Number |
22790893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
IWASHIMA Yoshio 独立行政法人国立循環器病研究センター, 腎臓科, 医長 (80448068)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 内分泌学 |
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| Research Abstract |
Adiponectin is an adipose tissue-specific collagen-like factor, and was previously reported to be associated with obesity and diabetes. A genetic investigation revealed one new polymorphism which more frequently showed lower concentrations of adiponectin, but not associated with hypoadiponectinemia-related diseases. This mutant protein showed a different oligomerization state of its monomer to the wild-type as determined by SDS page. The results of composition analysis suggested the importance of post-translational modifications analysis as well as amino acid sequences to clarification of pathophysiological role of adiponectin.
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