2012 Fiscal Year Final Research Report
Development of a new therapeutic approach against chemo-resistance of leukemic stem cells by bone marrow microenvironment
| Project/Area Number |
22790907
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | National Hospital Organization Nagoya Medical Center |
|---|
Principal Investigator |
MIYATA Yasuhiko 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 血液内科, 医長 (40467303)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 血液腫瘍学 |
|---|
| Research Abstract |
Direct contact with bone marrow stromal cells provides CML-derived cell lines with dormancy similar to stem cells and induced-drug resistance. In these cells, up-regulation of anti-apoptotic protein BCL-2 and p53 was observed and was thought to lead to this resistance, suggesting that the molecular targeted therapy toward these proteins could be reasonable. Moreover, up-regulation of BCR-ABL protein and elongation of BCR-ABL mRNA were observed by contact with stromal cells. This indicates that cell-to-cell contact may be involved in post-transcriptional regulation of mRNA.
|
